"RIV/68378050:_____/07:00097138" . "Vitamins and Hormones" . "Vitamin E analogues and immune response in cancer treatment"@en . "Vitamin E analogues and immune response in cancer treatment"@en . . "Neu\u017Eil, Ji\u0159\u00ED" . "458051" . "Analogy vitaminu E a imunitn\u00ED odpov\u011B\u010F p\u0159i l\u00E9\u010Den\u00ED rakoviny"@cs . . "[BB21E3A46E48]" . "76" . . "Chemotherapeutic drugs induce both proliferation arrest and apoptosis; however, some cancer cells become resistant. The suppression of the immune system by chemotherapeutic agents promotes the development and propagation of various malignancies, and maintain a cytokine milieu that favors proliferation by inhibiting apoptosis. A novel approach is based on a synergistic effect of different anticancer agents with different modes of action. Recently, a redox-silent analogue of vitamin E, \u03B1 tocopheryl succinate (\u03B1 TOS), has come into focus due to its anticancer properties. It exerts pleiotropic responses in malignant cells leading to cell cycle arrest, differentiation, and apoptosis. Apart from its role in killing cancer cells, \u03B1 TOS affects expression of genes in a subapoptotic manner. Here, we review recent findings on a cooperative antitumor effect when \u03B1 TOS was combined with immunological agents. It suggests a novel strategy for cancer treatment involving enhanced immune surveillance." . . "RIV/68378050:_____/07:00097138!RIV08-AV0-68378050" . . . "Chemotherapeutic drugs induce both proliferation arrest and apoptosis; however, some cancer cells become resistant. The suppression of the immune system by chemotherapeutic agents promotes the development and propagation of various malignancies, and maintain a cytokine milieu that favors proliferation by inhibiting apoptosis. A novel approach is based on a synergistic effect of different anticancer agents with different modes of action. Recently, a redox-silent analogue of vitamin E, \u03B1 tocopheryl succinate (\u03B1 TOS), has come into focus due to its anticancer properties. It exerts pleiotropic responses in malignant cells leading to cell cycle arrest, differentiation, and apoptosis. Apart from its role in killing cancer cells, \u03B1 TOS affects expression of genes in a subapoptotic manner. Here, we review recent findings on a cooperative antitumor effect when \u03B1 TOS was combined with immunological agents. It suggests a novel strategy for cancer treatment involving enhanced immune surveillance."@en . "Vitamin E analogues and immune response in cancer treatment" . "0083-6729" . "29"^^ . . . "Tomasetti, M." . . "463;491" . "-" . "Z(AV0Z50520514), Z(AV0Z50520701)" . "1"^^ . "2"^^ . "vitamin E analogues; inducers of apoptosis; immune surveillance"@en . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Vitamin E analogues and immune response in cancer treatment" . . "Chemoterapeutika indukuj\u00ED jak zastaven\u00ED d\u011Blen\u00ED, tak apopt\u00F3zu; ov\u0161em n\u011Bkter\u00E9 rakovinn\u00E9 bu\u0148ky se k nim st\u00E1vaj\u00ED rezistentn\u00EDmi. Potla\u010Den\u00ED imunitn\u00EDho syst\u00E9mu chemoterapeutiky podporuje v\u00FDvoj a mno\u017Een\u00ED r\u016Fzn\u00FDch malignit a tak\u00E9 udr\u017Euje cytokinov\u00E9 prost\u0159ed\u00ED favorizuj\u00EDc\u00ED d\u011Blen\u00ED inhibov\u00E1n\u00EDm apopt\u00F3zy. Nov\u00FD p\u0159\u00EDstup je zalo\u017Een na synergistick\u00E9m vlivu r\u016Fzn\u00FDch protirakovinn\u00FDch prost\u0159edk\u016F s r\u016Fzn\u00FDm zp\u016Fsobem p\u016Fsoben\u00ED. Ned\u00E1vno byla pozornost zam\u011B\u0159ena na redoxn\u011B-neaktivn\u00ED analog vitaminu E, \u03B1-tokoferylsukcin\u00E1t, na z\u00E1klad\u011B jeho protirakovinn\u00FDch vliv\u016F. Vykazuje pleiotropn\u00ED odpov\u011Bdi v malign\u00EDch bu\u0148k\u00E1ch vedouc\u00ED k zastaven\u00ED bun\u011B\u010Dn\u00E9ho cyklu, diferenciaci a apopt\u00F3ze. Krom\u011B jeho \u00FAlohy v zab\u00EDjen\u00ED rakovinn\u00FDch bun\u011Bk, \u03B1 TOS ovliv\u0148uje expresi gen\u016F na subapoptick\u00E9 \u00FArovni. Zde shrnujeme sou\u010Dasn\u00E9 poznatky o kooperativn\u00EDm protin\u00E1dorov\u00E9m vlivu \u03B1 TOS, pokud je kombinov\u00E1n s imunologick\u00FDmi agens. Nazna\u010Duje to mo\u017Enost vyu\u017E\u00EDt novou strategii pro l\u00E9\u010Den\u00ED rakoviny zahrnuj\u00EDc\u00ED zv\u00FD\u0161en\u00FD imunitn\u00ED dozor."@cs . . . "Analogy vitaminu E a imunitn\u00ED odpov\u011B\u010F p\u0159i l\u00E9\u010Den\u00ED rakoviny"@cs . . .