"Deletion of the LIME adaptor protein minimally affects T and B cell development and function"@en . . . . "Malissen, M." . "LIME is a transmembrane adaptor that associates with the Lck, Fyn and Csk. To delineate the role of LIME in vivo, LIME-deficient mice were generated. The absence of LIME impeded neither the development nor the function of B and T cells. TCR transgenic mice deprived of LIME showed, however, a 1.8-fold enhancement in positive selection. Since B cells and activated T cells express LIME and the related adaptor NTAL, mice lacking both adaptors were generated. Double-deficient mice showed no defect in the development and function of B and T cells, and the lack of LIME had no effect on the autoimmune syndrome that develops in aged NTAL-deficient mice. In contrast to a previous report, we further showed that this autoimmune syndrome develops in the absence of T cells. Therefore, our in vivo results demonstrate that LIME has no seminal role in the signaling cassette operated by antigen receptors and coreceptors." . . "11"^^ . . "Schmidr-Giese, A." . "13"^^ . . "Wang, Y." . "European Journal of Immunology" . . "LIME je adaptorov\u00FD protein, kter\u00FD asociuje s Lck, Fyn a Csk. Pro ur\u010Den\u00ED funkce tohoto proteinu byly p\u0159ipraveny LIME-deficientn\u00ED my\u0161i. Absence LIME nem\u011Bla vliv na v\u00FDvoj a funkci B ani T lymfocyt\u016F. TCR transgenn\u00ED my\u0161i s chyb\u011Bj\u00EDc\u00EDm LIME ale vykazovaly 1.8-n\u00E1sobn\u00E9 zv\u00FD\u0161en\u00ED pozitivn\u00ED selekce. Byly p\u0159ipraveny tak\u00E9 my\u0161i, kter\u00FDm chyb\u011Bl jak LIME, tak podobn\u00FD adaptorov\u00FD protein NTAL. Dvojit\u011B deficientn\u00ED my\u0161i m\u011Bly norm\u00E1ln\u00ED v\u00FDvoj a funkci B a T lymfocyt\u016F a nep\u0159\u00EDtomnost LIME nem\u011Bla \u017E\u00E1dn\u00FD vliv na autoimunitn\u00ED syndrom, kter\u00FD se vyv\u00EDj\u00ED u star\u00FDch NTAL-deficientn\u00EDch my\u0161\u00ED. na rozd\u00EDl od d\u0159\u00EDv\u011Bj\u0161\u00ED zpr\u00E1vy je uk\u00E1z\u00E1no, \u017Ee tento autoimunitn\u00ED syndrom se vyv\u00EDj\u00ED i za absence T lymfocyt\u016F. Tyto in vivo v\u00FDsledky ukazuj\u00ED, \u017Ee, \u017Ee LIME nem\u00E1 \u017E\u00E1dn\u00FD z\u00E1sadn\u00ED v\u00FDznam pro signaliza\u010Dn\u00ED d\u011Bje iniciovan\u00E9 antigenn\u00EDmi receptory a koreceptory."@cs . "[7C25C8965591]" . "RIV/68378050:_____/07:00093990!RIV08-AV0-68378050" . "Simeoni, L." . "3259;3269" . . "416118" . . "Richelme, S." . . "P(1M0506), Z(AV0Z50520514)" . "3"^^ . . "Eliminace adaptorov\u00E9ho proteinu LIME jen minim\u00E1ln\u011B ovliv\u0148uje v\u00FDvoj a funkci T a B lymfocyt\u016F"@cs . . "11" . . . "Ho\u0159ej\u0161\u00ED, V\u00E1clav" . "Burkhart, S." . "37" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "LIME; adaptor protein; receptor"@en . "\u0160\u00EDmov\u00E1, \u0160\u00E1rka" . "Deletion of the LIME adaptor protein minimally affects T and B cell development and function" . "Eliminace adaptorov\u00E9ho proteinu LIME jen minim\u00E1ln\u011B ovliv\u0148uje v\u00FDvoj a funkci T a B lymfocyt\u016F"@cs . "Sansoni, A." . . "Deletion of the LIME adaptor protein minimally affects T and B cell development and function"@en . "Gr\u00E9goire, C." . . "Malissen, B." . "RIV/68378050:_____/07:00093990" . "Deletion of the LIME adaptor protein minimally affects T and B cell development and function" . . "LIME is a transmembrane adaptor that associates with the Lck, Fyn and Csk. To delineate the role of LIME in vivo, LIME-deficient mice were generated. The absence of LIME impeded neither the development nor the function of B and T cells. TCR transgenic mice deprived of LIME showed, however, a 1.8-fold enhancement in positive selection. Since B cells and activated T cells express LIME and the related adaptor NTAL, mice lacking both adaptors were generated. Double-deficient mice showed no defect in the development and function of B and T cells, and the lack of LIME had no effect on the autoimmune syndrome that develops in aged NTAL-deficient mice. In contrast to a previous report, we further showed that this autoimmune syndrome develops in the absence of T cells. Therefore, our in vivo results demonstrate that LIME has no seminal role in the signaling cassette operated by antigen receptors and coreceptors."@en . "Reinhold, D." . . "Angelisov\u00E1, Pavla" . . "0014-2980" .