"Journal of Cell Science" . . . "Evidence for protein 4.1B acting as a metastasis suppressor" . "We compared a non-metastasising sarcoma cell population with 3 related populations of increasing metastatic potential. Metastatic cells in vitro exhibited a significantly reduced incidence of actin stress fibres but enhanced motility and chemotaxis. We also investigated gene expression underlying progression to a metastatic phenotype by performing a microarray analysis of the 4 sarcoma populations. We identified a subset of genes with significantly altered expression levels between non-metastasising and metastasising cells in tissue culture and in primary tumours. One such gene, encoding protein 4.1B, is down-regulated in the metastatic cells. We propose that reduction of 4.1B in metastatic cells promotes the metastatic phenotype as a result of inducing loss of actin stress fibres and a concomitant increase in cell motility." . . . "Vesel\u00FD, Pavel" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "2"^^ . "Evidence for protein 4.1B acting as a metastasis suppressor"@en . "11"^^ . "Evidence for protein 4.1B acting as a metastasis suppressor" . "Pokorn\u00E1, Eva" . "Z(AV0Z50520514)" . "420839" . "4" . "5"^^ . "We compared a non-metastasising sarcoma cell population with 3 related populations of increasing metastatic potential. Metastatic cells in vitro exhibited a significantly reduced incidence of actin stress fibres but enhanced motility and chemotaxis. We also investigated gene expression underlying progression to a metastatic phenotype by performing a microarray analysis of the 4 sarcoma populations. We identified a subset of genes with significantly altered expression levels between non-metastasising and metastasising cells in tissue culture and in primary tumours. One such gene, encoding protein 4.1B, is down-regulated in the metastatic cells. We propose that reduction of 4.1B in metastatic cells promotes the metastatic phenotype as a result of inducing loss of actin stress fibres and a concomitant increase in cell motility."@en . "4.1B protein; metastasis; migration"@en . "Zicha, D." . "[F65FB5D42753]" . . "RIV/68378050:_____/07:00090065" . "606;616" . . . "Porovnali jsme nemetastazuj\u00EDc\u00ED populaci sarkomov\u00FDc bun\u011Bk s t\u0159emi odvozen\u00FDmi populacemi bun\u011Bk se zv\u00FD\u0161en\u00FDm metastatick\u00FDm potenci\u00E1lem. Metastazuj\u00EDc\u00ED bu\u0148ky vykazovaly signifikantn\u011B redukovan\u00FD v\u00FDskyt aktiniov\u00FDch stresov\u00FDch svazk\u016F ale zv\u00FD\u0161enou motilitu a chemotaxi. Tak\u00E9 jsme vy\u0161et\u0159ovali genovou expresi, kter\u00E1 podmi\u0148uje progresi k metastatick\u00E9mu fenotypu pomoc\u00ED microarray anal\u00FDzy v\u0161ech \u010Dty\u0159 sarkomov\u00FDch populac\u00ED. Identifikovali jsem podmno\u017Einu v\u00FDznamn\u011B zm\u011Bn\u011Bn\u00FDch \u00FArovn\u00ED exprese mezi nemetastazuj\u00EDc\u00EDmi a metastazuj\u00EDc\u00EDmi bu\u0148kami jak v bun\u011B\u010Dn\u00E9 kultu\u0159e tak v prim\u00E1rn\u00EDch n\u00E1dorech. U jednoho takov\u00E9ho genu, k\u00F3duj\u00EDc\u00EDho protein 4.1B, je v\u00FDznamn\u011B sn\u00ED\u017Eena exprese v metastazuj\u00EDc\u00EDch sarkomov\u00FDch populac\u00EDch. Jsme toho n\u00E1zoru, \u017Ee redukce 4.1B v metastazuj\u00EDc\u00EDch bu\u0148k\u00E1ch podporuje metastatick\u00FD fenotyp v d\u016Fsledku ztr\u00E1ty aktinov\u00FDch stresov\u00FDch svazk\u016F a sou\u010Dasn\u00E9ho zv\u00FD\u0161en\u00ED bun\u011B\u010Dn\u00E9 motility."@cs . . "Gray, C." . . "Evidence for protein 4.1B acting as a metastasis suppressor"@en . "D\u016Fkaz pro potla\u010Den\u00ED metastazov\u00E1n\u00ED proteinem 4.1B"@cs . "Cavanna, T." . "D\u016Fkaz pro potla\u010Den\u00ED metastazov\u00E1n\u00ED proteinem 4.1B"@cs . . . "RIV/68378050:_____/07:00090065!RIV08-AV0-68378050" . . "0021-9533" . . "120" . . . .