. . . "486568" . . "RIV/68378050:_____/06:00047757!RIV07-MZ0-68378050" . . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "0960-894X" . "The effect of 13 flavonoid derivatives on paclitaxel transport was investigated in two human breast cancer cell lines, adriamycin-sensitive and adriamycin-resistant. Some derivatives proved to be efficient modulators of paclitaxel transport in P-gp highly expressing resistant human breast cancer cells. They also were more efficient than natural flavonoids. These agents could increase the efficiency of chemotherapy with paclitaxel in such resistant cells. However, care should be taken of the fact that drug transport in the P-gp non-expressing tumors may be influenced quite differently due to other transporters. Further studies are needed to investigate whether these derivatives are sufficiently potent to increase the effect of P-gp transported anticancer drugs in vivo."@en . "4519;4525" . "P(GA305/04/0403), P(NL7567), Z(AV0Z50520514)" . "Modulace transportu paclitaxelu flavonoidov\u00FDmi deriv\u00E1ty v bu\u0148k\u00E1ch lidsk\u00E9ho n\u00E1doru prsu. Existuje vztah mezi vazebnou afinitou k NBD P-gp a modulac\u00ED transportu?"@cs . "Modulace transportu paclitaxelu flavonoidov\u00FDmi deriv\u00E1ty v bu\u0148k\u00E1ch lidsk\u00E9ho n\u00E1doru prsu. Existuje vztah mezi vazebnou afinitou k NBD P-gp a modulac\u00ED transportu?"@cs . "Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport?"@en . "Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport?" . "The effect of 13 flavonoid derivatives on paclitaxel transport was investigated in two human breast cancer cell lines, adriamycin-sensitive and adriamycin-resistant. Some derivatives proved to be efficient modulators of paclitaxel transport in P-gp highly expressing resistant human breast cancer cells. They also were more efficient than natural flavonoids. These agents could increase the efficiency of chemotherapy with paclitaxel in such resistant cells. However, care should be taken of the fact that drug transport in the P-gp non-expressing tumors may be influenced quite differently due to other transporters. Further studies are needed to investigate whether these derivatives are sufficiently potent to increase the effect of P-gp transported anticancer drugs in vivo." . "Gut, I." . "V\u00E1clav\u00EDkov\u00E1, R." . "Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport?"@en . "Boumendjel, A." . "7"^^ . "RIV/68378050:_____/06:00047757" . "2"^^ . . . . "Ehrlichov\u00E1, Marie" . . . "\u00DA\u010Dinek 13 flavonoidov\u00FDch deriv\u00E1t\u016F byl zkoum\u00E1n u dvou bun\u011B\u010Dn\u00FDch lini\u00ED lidsk\u00E9ho n\u00E1doru prsu odoln\u00FDch v\u016F\u010Di adriamycinu a ciliv\u00FDch na tuto l\u00E1tku. N\u011Bkter\u00E9 tyto deriv\u00E1ty napom\u00E1haly transportu paxlitaxelu v rezistentn\u00EDch bu\u0148k\u00E1ch vysoce exprimuj\u00EDc\u00EDch P-gp. Byly tak\u00E9 \u00FA\u010Dinn\u011Bj\u0161\u00ED ne\u017E p\u0159irozen\u00E9 flavonoidy. Tyto l\u00E1tky by mohly \u00FA\u010Dinn\u011B napom\u00E1hat chemoterapii paclitaxelem u t\u011Bchto rezistentn\u00EDch bun\u011Bk. Je v\u0161ak t\u0159eba vz\u00EDt v \u00FAvahu, \u017Ee transport terapeutick\u00FDch l\u00E1tek v bu\u0148k\u00E1ch neexprimuj\u00EDc\u00EDch P-gp m\u016F\u017Ee b\u00FDt odli\u0161n\u00FD d\u00EDky vlivu dal\u0161\u00EDch p\u0159ena\u0161e\u010D\u016F. Ke zji\u0161t\u011Bn\u00ED, zda tyto deriv\u00E1ty maj\u00ED dostate\u010Dn\u00FD vliv na zv\u00FD\u0161en\u00ED \u00FA\u010Dinku protin\u00E1dorov\u00FDch l\u00E1tek p\u0159en\u00E1\u0161en\u00FDch P-gp in vivo, je t\u0159eba dal\u0161\u00EDch studi\u00ED."@cs . . "5"^^ . . . "Bioorganic and Medicinal Chemistry Letters" . "[0C4958A10C66]" . "14" . . . . "paclitaxel; multidrug resistance; flavonoid derivatives"@en . . . "13" . "Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport?" . "Kov\u00E1\u0159, Jan" .