"[CDB7FCB0948A]" . "RIV/68378050:_____/06:00031432" . . "Lipoldov\u00E1, Marie" . "Nature Reviews Genetics" . . . . . . "Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis" . "12"^^ . "Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis"@en . "7" . "4" . "Demant, P." . "Vn\u00EDmavost k infek\u010Dn\u00EDmu onemocn\u011Bn\u00ED je ovliv\u0148ov\u00E1na mnoha geny hostitele. Mnoho z nich zahrnujeme mezi lokusy kontroluj\u00EDc\u00ED kvantitativn\u00ED znaky (QTL), kter\u00E9 maj\u00ED n\u00EDzkou penentranci a kter\u00E9 je proto u \u010Dlov\u011Bka obt\u00ED\u017En\u00E9 mapovat. Leishmani\u00E1za je podrobn\u011B studovan\u00E1 infek\u010Dn\u00ED choroba projevuj\u00EDc\u00ED se mno\u017Estv\u00EDm symptom\u016F a dob\u0159e popsan\u00FDch imunologick\u00FDch reakc\u00ED. My\u0161\u00ED modely tohoto onemocn\u011Bn\u00ED vedly k nalezen\u00ED v\u00EDce ne\u017E 20 QTL, kter\u00E9 kontroluj\u00ED vn\u00EDmavost. Studium t\u011Bchto lokus\u016F p\u0159ineslo v\u00FDznamn\u00FD vklad k na\u0161emu pochopen\u00ED odpov\u011Bdi hostitele k infekci. Funk\u010Dn\u00ED efekty jednotliv\u00FDch QTL se velmi odli\u0161ovaly, co\u017E nazna\u010Dilo, \u017Ee jsou regulov\u00E1ny jako s\u00ED\u0165 vz\u00E1jemn\u00FDch vztah\u016F. N\u011Bkolik z QTL, kter\u00E9 kontroluj\u00ED odpov\u011B\u010F k leishmani\u00E1ze, pravd\u011Bpodobn\u011B ovliv\u0148uje tak\u00E9 vn\u00EDmavost k dal\u0161\u00EDm infekc\u00EDm, co\u017E nazna\u010Duje, \u017Ee jejich charakterizace p\u0159isp\u011Bje k obecn\u00E9mu pochopen\u00ED vn\u00EDmavosti k infek\u010Dn\u00EDm chorob\u00E1m."@cs . "476874" . "Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis" . . "Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis"@en . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "RIV/68378050:_____/06:00031432!RIV06-AV0-68378050" . "Genetick\u00E1 susceptibilita k infek\u010Dn\u00EDm chorob\u00E1m: pohled z my\u0161\u00EDch model\u016F leishmani\u00E1zy"@cs . "P(GA310/03/1381), Z(AV0Z50520514)" . . . . . "1"^^ . "leishmaniasis; susceptibility to infectious disease; modifying genes"@en . "1471-0056" . . "Susceptibility to infectious disease is influenced by multiple host genes, most of which are low penetrance QTLs that are difficult to map in humans. Leishmaniasis is a well-studied infectious disease with a variety of symptoms and well-defined immunological features. Mouse models of this disease have revealed more than 20 QTLs as being susceptibility genes, studies of which have made important contributions to our understanding of the host response to infection. The functional effects of individual QTLs differ widely, indicating a networked regulation of these effects. Several of these QTLs probably also influence susceptibility to other infections, indicating that their characterization will contribute to our understanding of susceptibility to infectious disease in general."@en . "2"^^ . "294;305" . . . . "Susceptibility to infectious disease is influenced by multiple host genes, most of which are low penetrance QTLs that are difficult to map in humans. Leishmaniasis is a well-studied infectious disease with a variety of symptoms and well-defined immunological features. Mouse models of this disease have revealed more than 20 QTLs as being susceptibility genes, studies of which have made important contributions to our understanding of the host response to infection. The functional effects of individual QTLs differ widely, indicating a networked regulation of these effects. Several of these QTLs probably also influence susceptibility to other infections, indicating that their characterization will contribute to our understanding of susceptibility to infectious disease in general." . "Genetick\u00E1 susceptibilita k infek\u010Dn\u00EDm chorob\u00E1m: pohled z my\u0161\u00EDch model\u016F leishmani\u00E1zy"@cs . . .