. . . . "RIV/68378050:_____/06:00030963!RIV06-AV0-68378050" . . "CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues"@en . . . "[2B924CD85E84]" . "2"^^ . . "Syncytin-1 je obalov\u00FD glykoprotein k\u00F3dovan\u00FD jedn\u00EDm z lidsk\u00FDch endogenn\u00EDch retrovir\u016F W. Je exprimov\u00E1n v\u00FDhradn\u011B v placent\u00E1ln\u00EDm trofoblastu, kde se \u00FA\u010Dastn\u00ED spl\u00FDv\u00E1n\u00ED bun\u011Bk p\u0159i diferenciaci syncytiotrofoblastu. V jin\u00FDch tk\u00E1n\u00EDch v\u0161ak mus\u00ED b\u00FDt exprese syncytinu-1 p\u0159\u00EDsn\u011B regulov\u00E1na, proto\u017Ee n\u00E1hodn\u00E9 f\u00FAze bun\u011Bk by mohly ohrozit organizaci a integritu tk\u00E1n\u00ED. Popisujeme zde opa\u010Dn\u00FD vztah metylace CpG 5' dlouh\u00E9 koncov\u00E9 repetice syncytinu-1 k jeho expresi. Na\u0161e \u00FAdaje o metylaci syncytinu-1 v placent\u011B, jin\u00FDch prim\u00E1rn\u00EDch bu\u0148k\u00E1ch a bun\u011B\u010Dn\u00FDch lini\u00EDch neexprimuj\u00EDc\u00EDch syncytin-1 ukazuj\u00ED, \u017Ee metylace CpG hraje z\u00E1sadn\u00ED roli v potla\u010Den\u00ED transkripce syncytinu-1 v neplacent\u00E1ln\u00EDch tk\u00E1n\u00EDch a naopak, demetylace promotoru syncytinu-1 v trofoblastu je z\u00E1kladn\u00EDm p\u0159edpokladem pro jeho expresi a pro diferenciaci mnohajadern\u00E9ho syncytiotrofoblastu."@cs . "1011;1020" . "Syncytin-1 is a captive envelope glycoprotein encoded by one of human endogenous retroviruses W. It is expressed exclusively in the placental trophoblast where it participates in cell-to-cell fusion during differentiation of syncytiotrophoblast. In other tissues, however, syncytin-1 expression must be kept in check because inadvertent cell fusion might be dangerous for tissue organization and integrity. We describe here an inverse correlation between CpG methylation of syncytin-1 5' long terminal repeat and its expression. Our data on syncytin-1 methylation in the placenta, other primary cells and cell lines non-expressing syncytin-1 document that CpG methylation plays a principal role in the transcriptional suppression of syncytin-1 in non-placental tissues, and, in contrast, demethylation of the syncytin-1 promoter in trophoblast is a prerequisite for its expression and differentiation of multinucleated syncytiotrophoblast." . . "CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues"@en . "syncytin-1; trophoblast; DNA methylation"@en . "P(GA204/05/0939), P(IAA5052207), Z(AV0Z50520514)" . "Hejnar, Ji\u0159\u00ED" . . . "Syncytin-1 is a captive envelope glycoprotein encoded by one of human endogenous retroviruses W. It is expressed exclusively in the placental trophoblast where it participates in cell-to-cell fusion during differentiation of syncytiotrophoblast. In other tissues, however, syncytin-1 expression must be kept in check because inadvertent cell fusion might be dangerous for tissue organization and integrity. We describe here an inverse correlation between CpG methylation of syncytin-1 5' long terminal repeat and its expression. Our data on syncytin-1 methylation in the placenta, other primary cells and cell lines non-expressing syncytin-1 document that CpG methylation plays a principal role in the transcriptional suppression of syncytin-1 in non-placental tissues, and, in contrast, demethylation of the syncytin-1 promoter in trophoblast is a prerequisite for its expression and differentiation of multinucleated syncytiotrophoblast."@en . . "Experimental Cell Research" . "Metylace CpG potla\u010Duje transkrip\u010Dn\u00ED aktivitu lidsk\u00E9ho syncytinu-1 v neplacent\u00E1ln\u00EDch tk\u00E1n\u00EDch"@cs . "5"^^ . . "CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues" . . "0014-4827" . . . "469958" . . "Matou\u0161kov\u00E1, Magda" . "Pajer, Petr" . . . "5"^^ . "CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues" . . . "312" . "Pavl\u00ED\u010Dek, Adam" . "RIV/68378050:_____/06:00030963" . "Metylace CpG potla\u010Duje transkrip\u010Dn\u00ED aktivitu lidsk\u00E9ho syncytinu-1 v neplacent\u00E1ln\u00EDch tk\u00E1n\u00EDch"@cs . . "Bla\u017Ekov\u00E1, Jana" . "7" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" .