"540590" . "Na \u00DAstavu molekul\u00E1rn\u00ED genetiky AV \u010CR byly z cDNA hybridomov\u00FDch bun\u011Bk produkuj\u00EDc\u00EDch imunoglobulin MEM 97 molekul\u00E1rn\u00EDm klonov\u00E1n\u00EDm z\u00EDsk\u00E1ny cDNA k\u00F3duj\u00EDc\u00ED variabiln\u00ED oblast\u00ED lehk\u00E9ho a t\u011B\u017Ek\u00E9ho \u0159et\u011Bzce a zkonstruov\u00E1n plasmid exprese scFv molekuly sest\u00E1vaj\u00EDc\u00ED z variabiln\u00ED oblasti lehk\u00E9ho \u0159et\u011Bzce, kr\u00E1tk\u00E9 spojky a variabiln\u00ED oblasti t\u011B\u017Ek\u00E9ho \u0159et\u011Bzce, p\u0159i\u010Dem\u017E spojka vynucuje zk\u0159\u00ED\u017Eenou dimerizaci b\u00EDlkovinn\u00FDch molekul; postupy rekombinantn\u00ED exprese a purifikace byly optimalizov\u00E1ny. Prototypov\u00E1 scFv protil\u00E1tka, plasmid exprese a protokoly technologie produkce byly smluvn\u011B p\u0159ed\u00E1ny spole\u010Dnosti EXBIO Praha a.s. na z\u00E1klad\u011B smlouvy mezi t\u011Bmito dv\u011Bma spolu\u0159e\u0161iteli grantov\u00E9ho projektu FD K3/001."@cs . . "Recombinant diabody format of the antibody MEM 97"@en . . . "Such\u00E1nek, M." . . . "Na \u00DAstavu molekul\u00E1rn\u00ED genetiky AV \u010CR byly z cDNA hybridomov\u00FDch bun\u011Bk produkuj\u00EDc\u00EDch imunoglobulin MEM 97 molekul\u00E1rn\u00EDm klonov\u00E1n\u00EDm z\u00EDsk\u00E1ny cDNA k\u00F3duj\u00EDc\u00ED variabiln\u00ED oblast\u00ED lehk\u00E9ho a t\u011B\u017Ek\u00E9ho \u0159et\u011Bzce a zkonstruov\u00E1n plasmid exprese scFv molekuly sest\u00E1vaj\u00EDc\u00ED z variabiln\u00ED oblasti lehk\u00E9ho \u0159et\u011Bzce, kr\u00E1tk\u00E9 spojky a variabiln\u00ED oblasti t\u011B\u017Ek\u00E9ho \u0159et\u011Bzce, p\u0159i\u010Dem\u017E spojka vynucuje zk\u0159\u00ED\u017Eenou dimerizaci b\u00EDlkovinn\u00FDch molekul; postupy rekombinantn\u00ED exprese a purifikace byly optimalizov\u00E1ny. Prototypov\u00E1 scFv protil\u00E1tka, plasmid exprese a protokoly technologie produkce byly smluvn\u011B p\u0159ed\u00E1ny spole\u010Dnosti EXBIO Praha a.s. na z\u00E1klad\u011B smlouvy mezi t\u011Bmito dv\u011Bma spolu\u0159e\u0161iteli grantov\u00E9ho projektu FD K3/001." . . . . . "realiz\u00E1tor EXBIO Praha a.s., I\u010C 25548611" . "Rekombinantn\u00ED \u201Ediabody\u201C form\u00E1t protil\u00E1tky MEM 97"@cs . . . "Protil\u00E1tka ve form\u00E1tu \u201Ediabody\u201C, specifick\u00E1 k lidsk\u00E9 lymfocyt\u00E1rn\u00ED povrchov\u00E9 b\u00EDlkovin\u011B CD20 (nadm\u011Brn\u011B exprimovan\u00E9 na lymfomov\u00FDch bu\u0148k\u00E1ch), u\u017Eite\u010Dn\u00E1 ke zna\u010Den\u00ED radionuklidy pro v\u00FDvoj nov\u00FDch radiofarmak" . . "MEM 97 diabody" . . "P(FD-K3/001), Z(AV0Z5052915)" . "2"^^ . "Rekombinantn\u00ED \u201Ediabody\u201C form\u00E1t protil\u00E1tky MEM 97"@cs . "protil\u00E1tka m\u00E1 ov\u011B\u0159enou komer\u010Dn\u00ED hodnotu" . . . . . "Rekombinantn\u00ED \u201Ediabody\u201C form\u00E1t protil\u00E1tky MEM 97" . . "1"^^ . "Recombinant diabody format of the antibody MEM 97"@en . . "Rekombinantn\u00ED \u201Ediabody\u201C form\u00E1t protil\u00E1tky MEM 97" . "Sedl\u00E1\u010Dek, Juraj" . "At the Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, cDNAs encoding the variable regions of the light chain and the heavy chain were isolated from hybridoma cells producing immunoglobulin MEM 97, an expression plasmid for the molecule comprising the light chain variable region, a short linker (promoting dimerization of the protein product) and the heavy chain variable region was constructed; and the recombinant expression and purification procedures were optimized. The prototype scFv antibody, the expression plasmid and protocols of the production technology were transferred from the Institute of Molecular Genetics to the company EXBIO Praha a.s. on the basis of a contract concluded between these two participants of the grant project FD-K3/001."@en . "RIV/68378050:_____/05:00083087" . . . "CD20; diabody; expression plasmid"@en . "RIV/68378050:_____/05:00083087!RIV07-AV0-68378050" . "[2377DEF2EF5C]" .