"Minim\u00E1ln\u00ED zbytkov\u00E1 choroba (MRD), tedy p\u0159etrv\u00E1v\u00E1n\u00ED klonu leukemick\u00FDch bun\u011Bk u pacient\u016F po chemoterapii nebo transplantaci kmenov\u00FDch bun\u011Bk je v\u00E1\u017Enou komplikac\u00ED p\u0159i l\u00E9\u010Db\u011B. Byla vyvinuta rychl\u00E1, citliv\u00E1, spolehliv\u00E1 a levn\u00E1 metoda detekce klon\u00E1ln\u00ED p\u0159estavby v \u0159et\u011Bzci IgV(H), kter\u00E1 usnadn\u00ED sledov\u00E1n\u00ED MRD u pacient\u016F v pr\u016Fb\u011Bhu l\u00E9\u010Dby. Metoda vyu\u017E\u00EDv\u00E1 techniku RT-PCR s primery specifick\u00FDmi pro dan\u00E9ho pacienta."@cs . . "Cetkovsk\u00FD, P." . . "1" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "23;34" . "Touch-down reverse transcriptase-PCR detection of IgV(H) rearrangement and Sybr-Green-based real-time RT-PCR quantitation of minimal residual disease in patients with chronic lymphocytic leukemia" . "RIV/68378050:_____/05:00027994!RIV06-AV0-68378050" . "Touch-down reverse transcriptase-PCR detection of IgV(H) rearrangement and Sybr-Green-based real-time RT-PCR quantitation of minimal residual disease in patients with chronic lymphocytic leukemia"@en . . "minimal residual disease; chronic lymphocytic leukaemia; IgV(H) rearrangement"@en . . . . . "Detekce p\u0159estavby IgV(H) pomoc\u00ED \u201Ctouch-down\u201D RT-PCR a kvantifikace minim\u00E1ln\u00ED residu\u00E1ln\u00ED nemoci pomoc\u00ED Sybr-Green RT-PCR v re\u00E1ln\u00E9m \u010Dase u pacient\u016F s chronickou lymfocyt\u00E1rn\u00ED leukemi\u00ED"@cs . "P(NM7604), Z(AV0Z50520514), Z(MZ0UHKT2005)" . "Schwarz, J." . . "Touch-down reverse transcriptase-PCR detection of IgV(H) rearrangement and Sybr-Green-based real-time RT-PCR quantitation of minimal residual disease in patients with chronic lymphocytic leukemia"@en . "546949" . . "Pekov\u00E1, So\u0148a" . . "Patients with chronic lymphocytic leukemia (CLL) can relapse even after aggressive therapy. It is commonly assumed that to prevent relapse the level of minimal residual disease (MRD) should be as low as possible. We develop a robust and sensitive method for detection of the clonal immunoglobulin heavy-chain variable (IgV(H)) rearrangement in CLL and to introduce a highly sensitive and specific methodology for MRD monitoring in patients with CLL who undergo intensive treatment."@en . "Dvo\u0159\u00E1k, Michal" . . . "[2AA70FFCC28F]" . "Detekce p\u0159estavby IgV(H) pomoc\u00ED \u201Ctouch-down\u201D RT-PCR a kvantifikace minim\u00E1ln\u00ED residu\u00E1ln\u00ED nemoci pomoc\u00ED Sybr-Green RT-PCR v re\u00E1ln\u00E9m \u010Dase u pacient\u016F s chronickou lymfocyt\u00E1rn\u00ED leukemi\u00ED"@cs . "Patients with chronic lymphocytic leukemia (CLL) can relapse even after aggressive therapy. It is commonly assumed that to prevent relapse the level of minimal residual disease (MRD) should be as low as possible. We develop a robust and sensitive method for detection of the clonal immunoglobulin heavy-chain variable (IgV(H)) rearrangement in CLL and to introduce a highly sensitive and specific methodology for MRD monitoring in patients with CLL who undergo intensive treatment." . . "Molecular Diagnosis" . . . . . "6"^^ . "1084-8592" . . "Markov\u00E1, J." . "9" . "Pajer, Petr" . "Touch-down reverse transcriptase-PCR detection of IgV(H) rearrangement and Sybr-Green-based real-time RT-PCR quantitation of minimal residual disease in patients with chronic lymphocytic leukemia" . "12"^^ . . . "RIV/68378050:_____/05:00027994" . "3"^^ .