. "3"^^ . "Ojima, I." . . . "Naunyn-Schmiedeberg's Archiv of Pharmacology" . . . "Kuznetsova, L. V." . . "Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells"@en . . . "V\u00E1clav\u00EDkov\u00E1, R." . . . "9"^^ . . "Truksa, Jaroslav" . "Transport a cytotoxicita paclitaxelu, docetaxelu a nov\u00FDch taxan\u016F u lidsk\u00FDch bun\u011Bk n\u00E1dor\u016F prsu"@cs . "Kov\u00E1\u0159, Jan" . . . "372" . "Pepe, A." . "547137" . "Transport a cytotoxicita paclitaxelu, docetaxelu a nov\u00FDch taxan\u016F u lidsk\u00FDch bun\u011Bk n\u00E1dor\u016F prsu"@cs . "RIV/68378050:_____/05:00027660" . . . "Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells" . . "Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells"@en . "taxanes; uptake; ABC transporters"@en . "11"^^ . "0028-1298" . "P(GA305/04/0403), P(NL7567), Z(AV0Z50520514)" . "RIV/68378050:_____/05:00027660!RIV06-AV0-68378050" . . "1" . "Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells" . . "This study compared cytotoxicity and transport of paclitaxel and docetaxel with novel taxanes in human breast cancer cells. The cell lines examined differ expression of ABC membrane transporters. Reverse transcription-polymerase chain reaction revealed that NCI/ADR-RES cells expressed high levels of P-glycoprotein mRNA, which was absent in MDA-MB-435 cells, while the opposite was true for MRP2 mRNA. NCI/ADR-RES cells were more resistant to paclitaxel and to docetaxel than MDA-MB-435 cells, but almost equally sensitive to novel taxanes. This complied with the fact that NCI/ADR-RES cells absorbed almost 20-fold less [14C]paclitaxel, about 7-fold less docetaxel, and almost equal amounts of SB-T-1103, SB-T-1214, and SB-T-1216 as the MDA-MB-435 cells. SB-T-1103 and SB-T-1216 did not influence transport of paclitaxel, but SB-T-1214 decreased [14C]paclitaxel uptake in both cell lines indicating inhibition of uptake. This suggests that the novel taxanes are not inhibitors of P-glycoprotein."@en . "Gut, I." . "This study compared cytotoxicity and transport of paclitaxel and docetaxel with novel taxanes in human breast cancer cells. The cell lines examined differ expression of ABC membrane transporters. Reverse transcription-polymerase chain reaction revealed that NCI/ADR-RES cells expressed high levels of P-glycoprotein mRNA, which was absent in MDA-MB-435 cells, while the opposite was true for MRP2 mRNA. NCI/ADR-RES cells were more resistant to paclitaxel and to docetaxel than MDA-MB-435 cells, but almost equally sensitive to novel taxanes. This complied with the fact that NCI/ADR-RES cells absorbed almost 20-fold less [14C]paclitaxel, about 7-fold less docetaxel, and almost equal amounts of SB-T-1103, SB-T-1214, and SB-T-1216 as the MDA-MB-435 cells. SB-T-1103 and SB-T-1216 did not influence transport of paclitaxel, but SB-T-1214 decreased [14C]paclitaxel uptake in both cell lines indicating inhibition of uptake. This suggests that the novel taxanes are not inhibitors of P-glycoprotein." . "Chen, J." . . . "Ehrlichov\u00E1, Marie" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "Tato studie srovn\u00E1v\u00E1v\u00E1 cytotoxicitu a transport paclitaxel a docetaxelu s nov\u00FDmi taxany u lidsk\u00FDch bun\u011Bk n\u00E1dor\u016F prsu. Tyto zkouman\u00E9 bun\u011B\u010Dn\u00E9 linie se li\u0161\u00ED v expresi membr\u00E1nov\u00FDch ABC transport\u00E9r\u016F. Na z\u00E1klad\u011B reverzn\u00ED transkrip\u010Dn\u00ED polymer\u00E1zy bylo odhaleno, \u017Ee bu\u0148ky NCI/ADR-RES exprimuj\u00ED vy\u0161\u0161\u00ED hladinu P glycoproteinu na \u00FArovni mRNA, kter\u00FD chyb\u00ED u bun\u011Bk MDA-MB-435, u nich byla zv\u00FD\u0161en\u00E1 hladina MRP2. Bu\u0148ky NCI/ADR/RES jsou hodn\u011B rezistentn\u011Bj\u0161\u00ED v\u00FA\u010Di paclitaxelu a docetaxelu ne\u017E bu\u0148ky MDA-MB-435, ale ob\u011B linie podobn\u011B senzitivn\u00ED v\u00FA\u010Di nov\u00FDm taxan\u016Fm. Bu\u0148ky NCI/ADR-RES absorbuj\u00ED p\u0159ibli\u017En\u011B 20kr\u00E1t m\u00E9n\u011B [14C]paclitaxelu, 7 kr\u00E1t m\u00E9n\u011B docetaxelu a p\u0159ibli\u017En\u011B stejn\u011B nov\u00FDch taxan\u016F jako bu\u0148ky MDA-MB-435. SB-T-1103 a SB-T-1216 neovliv\u0148uj\u00ED transport paclitaxelu, ale SB-T-1214 sni\u017Euje uptake u obou bu\u0148\u011B\u010Dn\u00FDch lini\u00ED. To vede k z\u00E1v\u011Bru, \u017Ee nov\u00E9 taxany nejsou inhibitory P glykoproteinu."@cs . "95;105" . "[737D262FC7FD]" .