. "Lifting the fog in store-operated Ca2+ entry"@en . "Lifting the fog in store-operated Ca2+ entry"@en . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . "[C1AEB23A2DDF]" . "Lifting the fog in store-operated Ca2+ entry" . "Imunoreceptorov\u00E1 signalizace vede k uvoln\u011Bn\u00ED Ca2+ z cytoplasmatick\u00FDch z\u00E1sob\u00E1ren a n\u00E1sledn\u011B k vstupu Ca2+ do bu\u0148ky mechanismem SOCE (store-operated Ca2+ entrance). Ned\u00E1vn\u00E9 studie identifikovaly STIM1 (stromal interaction molecule 1) jako v\u00FDznamn\u00E9ho hr\u00E1\u010De p\u0159i SOCE. Za v\u00FDznamn\u00FD lze pova\u017Eovat n\u00E1lez, \u017Ee uvoln\u011Bn\u00ED Ca2+ ze z\u00E1sob\u00E1ren vede k rychl\u00E9 redistribuci STIM1 na endoplasmatick\u00E9m retikulu do shluk\u016F akumulovan\u00FDch v bl\u00EDzkosti plasmatick\u00E9 membr\u00E1ny. Kombinovan\u00E9 v\u00FDsledky nazna\u010Duj\u00ED, \u017Ee STIM1 funguje jako Ca2+ sensor v signaliza\u010Dn\u00EDch cest\u00E1ch propojuj\u00EDc\u00EDch sn\u00ED\u017Een\u00ED koncentrace Ca2+ a SOCE."@cs . "Mlha stoup\u00E1 v objas\u0148ov\u00E1n\u00ED z\u00E1sobami \u0159\u00EDzen\u00E9ho vstupu Ca2+"@cs . . "12" . . . . "2"^^ . "4"^^ . "plasma membrane; calcium uptake; stromal interaction molecule"@en . "Immunoreceptor signaling leads to Ca2+ release from intracellular stores, followed by a mysterious store-operated Ca2+ (SOC) entrance. Recent studies identified stromal interaction molecules (STIMs) as playing an essential role in SOC influx. Remarkably, Ca2+ store depletion induced a rapid redistribution of the endoplasmic reticulum STIM1 into puncta that accumulated near the plasma membrane. The combined data suggest that STIM1 functions as a Ca2+ sensor in the signaling pathways connecting Ca2+ store depletion to SOC entrance."@en . "Immunoreceptor signaling leads to Ca2+ release from intracellular stores, followed by a mysterious store-operated Ca2+ (SOC) entrance. Recent studies identified stromal interaction molecules (STIMs) as playing an essential role in SOC influx. Remarkably, Ca2+ store depletion induced a rapid redistribution of the endoplasmic reticulum STIM1 into puncta that accumulated near the plasma membrane. The combined data suggest that STIM1 functions as a Ca2+ sensor in the signaling pathways connecting Ca2+ store depletion to SOC entrance." . "2"^^ . "Lifting the fog in store-operated Ca2+ entry" . . . . . . "Mlha stoup\u00E1 v objas\u0148ov\u00E1n\u00ED z\u00E1sobami \u0159\u00EDzen\u00E9ho vstupu Ca2+"@cs . . . "RIV/68378050:_____/05:00026224!RIV06-AV0-68378050" . "Dr\u00E1berov\u00E1, Lubica" . . "26" . "528135" . . "Trends in Immunology" . . . . "1471-4906" . "RIV/68378050:_____/05:00026224" . "621;624" . "P(1M0506), P(IAA5052310), P(IBS5052201), Z(AV0Z5052915)" . "Dr\u00E1ber, Petr" .