. "Ho\u0159ej\u0161\u00ED, V\u00E1clav" . "RIV/68378050:_____/05:00021377" . "Slezakova, K." . "Godar, S." . . "Schiller, H. B." . . . "RIV/68378050:_____/05:00021377!RIV06-AV0-68378050" . . "1"^^ . "0021-9533" . "Weidle, U. H." . . "Apopt\u00F3za vyvolan\u00E1 v endoteli\u00E1ln\u00EDch bu\u0148k\u00E1ch TGF-beta zprost\u0159edkovan\u00E1 M6P/IGFII-R a mini-plasminogenem"@cs . . "apoptosis; TGF-beta; mini-plasminogen"@en . "546578" . "TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen"@en . "Muhammad, A." . "TGF-b must be activated from the latent form (LTGF-b) to induce biological responses. We report activation of TGF-b by co-operation of the mannose-6-phosphate/insulin-like-growth-factor-II receptor (CD222) and the u-PAR (CD87). Endothelial cells express CD222 and CD87 in a membrane complex; the association of these two receptors is essential for the release of active TGF-b in the transduced mouse fibroblast. Smooth-muscle cells, which express CD222 and CD87 at similar density to endothelial cells but not in complexed form, do not activate TGF-b. Mini-plasminogen is a high-affinity ligand for CD222 and is essential for the activation of TGF-b by the CD87-CD222 complex to induce apoptosis in endothelial cells. This specific mechanism of TGF-b-mediated apoptosis in endothelial cells is thus a potential novel target for treatment of pathological vascular disorders (e.g. tumor angiogenesis)."@en . "10"^^ . "118" . . . "Apopt\u00F3za vyvolan\u00E1 v endoteli\u00E1ln\u00EDch bu\u0148k\u00E1ch TGF-beta zprost\u0159edkovan\u00E1 M6P/IGFII-R a mini-plasminogenem"@cs . . "11"^^ . . "4577;4586" . "[296AC87BADB0]" . "Steinlein, P." . "Leksa, V." . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Stockinger, H." . "TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen" . "Fuertbauer, E." . "19" . . "Z(AV0Z5052915)" . "TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen"@en . "Tato pr\u00E1ce popisuje aktivaci cytokinu TGF-b kooperac\u00ED receptor\u016F: mannose-6-phosphate/insulin-like-growth-factor-II receptor (CD222) a u-PAR (CD87). Endotheli\u00E1ln\u00ED bu\u0148ky exprimuj\u00ED CD222 a CD87 v membr\u00E1nov\u00E9m komplexu; asociace t\u011Bchto receptor\u016F je z\u00E1sadn\u011B d\u016Fle\u017Eit\u00E1 pro uvoln\u011Bn\u00ED aktivn\u00EDho TGF-b v transdukovan\u00FDch my\u0161\u00EDch fibroblastech. Bu\u0148ky hladk\u00E9ho svalstva, kter\u00E9 tak\u00E9 exprimuj\u00ED CD222 a CD87, ale v nekomplexn\u00ED form\u011B, neaktivuj\u00ED TGF-b. Mini-plasminogen je vysokoafinn\u00EDm ligandem CD222 a je z\u00E1sadn\u011B d\u016Fle\u017Eit\u00FD pro aktivaci TGF-b komplexem CD87-CD222, pot\u0159ebnou k indukci apoptosy endotheli\u00E1ln\u00EDch bun\u011Bk. Tento mechanismus p\u0159edstavuje nov\u00FD potenci\u00E1ln\u00ED c\u00EDl pro l\u00E9\u010Dbu patologick\u00FDch vaskul\u00E1rn\u00EDch d\u011Bj\u016F (nap\u0159. n\u00E1dorov\u00E1 angiogenesa)."@cs . "TGF-b must be activated from the latent form (LTGF-b) to induce biological responses. We report activation of TGF-b by co-operation of the mannose-6-phosphate/insulin-like-growth-factor-II receptor (CD222) and the u-PAR (CD87). Endothelial cells express CD222 and CD87 in a membrane complex; the association of these two receptors is essential for the release of active TGF-b in the transduced mouse fibroblast. Smooth-muscle cells, which express CD222 and CD87 at similar density to endothelial cells but not in complexed form, do not activate TGF-b. Mini-plasminogen is a high-affinity ligand for CD222 and is essential for the activation of TGF-b by the CD87-CD222 complex to induce apoptosis in endothelial cells. This specific mechanism of TGF-b-mediated apoptosis in endothelial cells is thus a potential novel target for treatment of pathological vascular disorders (e.g. tumor angiogenesis)." . . "TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen" . "Journal of Cell Science" . . . "Binder, B. R." .