"Biochemical and Biophysical Research Communications" . . . "4" . "Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway"@en . "Salvatore, B. A." . . "Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway"@en . . . . "Z(AV0Z5052915)" . "Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway" . . "Analogy vitam\u00EDnu E vyvol\u00E1vaj\u00ED apopt\u00F3zu v bu\u0148k\u00E1ch n\u00E1doru prsu se zv\u00FD\u0161enou expres\u00ED HER2/erbB2 signalizac\u00ED mitochondri\u00E1ln\u00ED dr\u00E1hou"@cs . "Wang, X.-F." . "We investigated whether alpha-TOS and several novel vitamin E analogs kill breast cancer cells overexpressing the antiapoptotic receptor protein HER2/erbB2. The agents induced apoptosis at comparable levels in both erbB2-low and -high cells. Generation of ROS preceded mitochondrial destabilization and execution of apoptosis. Dissipation of DeltaPsi(m) was followed by cytochrome c and Smac/Diablo re-localization and caspase-dependent cleavage of death substrate. A resistance to apoptosis for the corresponding rho(0) counterparts confirmed a critical dependency for mitochondria during the induction of apoptosis in breast cancer cells mediated by VE analogs and linked apoptosis to generation of radicals. alpha-TOS thus causes efficient apoptosis in breast cancer cells independent of their erbB2 status. Since erbB2 is frequently over-expressed in breast cancers and renders the neoplastic disease resistant to established treatment, our findings are of clinical interest."@en . . . "Witting, P. K." . . "282;289" . . "[B5563FE9DE19]" . "Analogy vitam\u00EDnu E vyvol\u00E1vaj\u00ED apopt\u00F3zu v bu\u0148k\u00E1ch n\u00E1doru prsu se zv\u00FD\u0161enou expres\u00ED HER2/erbB2 signalizac\u00ED mitochondri\u00E1ln\u00ED dr\u00E1hou"@cs . . "1"^^ . "RIV/68378050:_____/05:00001362!RIV06-AV0-68378050" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "vitamin E analogs; apoptosis; ErbB2"@en . "4"^^ . . . "326" . "0006-291X" . . "Neu\u017Eil, Ji\u0159\u00ED" . "548951" . "Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway" . "8"^^ . "We investigated whether alpha-TOS and several novel vitamin E analogs kill breast cancer cells overexpressing the antiapoptotic receptor protein HER2/erbB2. The agents induced apoptosis at comparable levels in both erbB2-low and -high cells. Generation of ROS preceded mitochondrial destabilization and execution of apoptosis. Dissipation of DeltaPsi(m) was followed by cytochrome c and Smac/Diablo re-localization and caspase-dependent cleavage of death substrate. A resistance to apoptosis for the corresponding rho(0) counterparts confirmed a critical dependency for mitochondria during the induction of apoptosis in breast cancer cells mediated by VE analogs and linked apoptosis to generation of radicals. alpha-TOS thus causes efficient apoptosis in breast cancer cells independent of their erbB2 status. Since erbB2 is frequently over-expressed in breast cancers and renders the neoplastic disease resistant to established treatment, our findings are of clinical interest." . "RIV/68378050:_____/05:00001362" . "Zkoumali jsme, zda alfa-TOS a \u0159ada nov\u00FDch analog\u016F vitam\u00EDnu E zab\u00EDj\u00ED bu\u0148ky n\u00E1doru prsu se zv\u00FD\u0161enou expres\u00ED antiapoptotick\u00E9ho receptorov\u00E9ho proteinu HER2/erbB2. Zkouman\u00E9 l\u00E1tky vyvol\u00E1valy apopt\u00F3zu na srovnateln\u00E9 \u00FArovni u bun\u011Bk s n\u00EDzkou i vysokou hladinou erbB2. P\u0159ed destabilizac\u00ED mitochondri\u00ED a spu\u0161t\u011Bn\u00EDm apopt\u00F3zy doch\u00E1zelo k tvorb\u011B ROS. Ztr\u00E1tu potenci\u00E1lu delta-ps\u00ED(m) n\u00E1sledovala relokalizace cytochromu c a Smac/Diablo a tak\u00E9 \u0161t\u011Bpen\u00ED substr\u00E1tu bun\u011B\u010Dn\u00E9 smrti z\u00E1visl\u00E9 na kasp\u00E1z\u00E1ch. Odolnost v\u016F\u010Di apopt\u00F3ze u odpov\u00EDdaj\u00EDc\u00EDch prot\u011Bj\u0161k\u016F rho(0) potvrdila kritickou z\u00E1vislost na mitochondri\u00EDch b\u011Bhem indukce apopt\u00F3zy v bu\u0148k\u00E1ch n\u00E1doru prsu vyvolanou analogy VE a propojila apopt\u00F3zu s tvorbou radik\u00E1l\u016F. Alfa-TOS tedy vyvol\u00E1v\u00E1 \u00FA\u010Dinnou apopt\u00F3zu u bun\u011Bk n\u00E1doru prsu nez\u00E1visle na jejich expresi erbB2. Jeliko\u017E exprese erbB2 je u n\u00E1doru prsu \u010Dasto zv\u00FD\u0161ena a vyvol\u00E1v\u00E1 u neopl\u00E1zi\u00ED odolnost v\u016F\u010Di zaveden\u00E9 l\u00E9\u010Db\u011B, na\u0161e poznatky maj\u00ED klinick\u00FD v\u00FDznam."@cs .