. "Iron deprivation induces apoptosis in some cultured tumor cells while other cells are resistant. The aim of the study is to contribute to our understanding of the mechanisms involved in cell death induction by iron deprivation in human tumor cells. We focused on p53 activation and on the mitochondrial pathway of caspase activation. We detected a slight increase in the mitochondrial membrane potential as the only change in sensitive human cells due to iron deprivation. Therefore, we decided to look at the activation of the executioner caspases (caspase-6, caspase-7) and the possible interactions of caspases with their cell inhibitors"@en . "4"^^ . "569003" . . . "127;128" . "P(GA301/01/0041)" . "37-" . . "Iron deprivation induces apoptosis via differing mechanisms in human and mouse tumor cells" . . "Nedostatek \u017Eeleza vyvol\u00E1v\u00E1 v lidsk\u00FDch a my\u017E\u00EDch n\u00E1dorov\u00FDch bu\u0148k\u00E1ch apopt\u00F3zu odli\u0161n\u00FDmi mechanismy"@cs . "Koc, Michal" . "apoptosis; iron deprivation; mitochondrial pathway"@en . . . . "2" . "Na\u010Fov\u00E1, Zuzana" . "RIV/68378050:_____/04:00105395" . "Nedostatek \u017Eeleza vyvol\u00E1v\u00E1 v n\u011Bkter\u00FDch kultivovan\u00FDch n\u00E1dorov\u00FDch bu\u0148k\u00E1ch apopt\u00F3zu, zat\u00EDmco jin\u00E9 bu\u0148ky jsou odoln\u00E9. C\u00EDlem t\u00E9to studie bylo p\u0159isp\u011Bt k objasn\u011Bn\u00ED mechanism\u016F pod\u00EDlej\u00EDc\u00EDch se na vyvol\u00E1n\u00ED bun\u011B\u010Dn\u00E9 smrti nedostatkem \u017Eeleza v lidsk\u00FDch n\u00E1dorov\u00FDch bu\u0148k\u00E1ch. Zam\u011B\u0159ili jsme se na aktivaci p53 a na mitochondri\u00E1ln\u00ED dr\u00E1hu aktivace kasp\u00E1z. Zjistili jsme slab\u00E9 zv\u00FD\u0161en\u00ED potenci\u00E1lu mitochondri\u00E1ln\u00ED membr\u00E1ny jako jedinou zm\u011Bnu v citliv\u00FDch lidsk\u00FDch bu\u0148k\u00E1ch zp\u016Fsobenou nedostatkem \u017Eeleza. Proto jsme se rozhodli prostudovat aktivaci v\u00FDkonn\u00FDch kasp\u00E1z (kasp\u00E1za-6, kasp\u00E1za-7) a mo\u017En\u00E9 interakce kasp\u00E1z s jejich bun\u011B\u010Dn\u00FDmi inhibitory"@cs . . "Cell Proliferation" . "Iron deprivation induces apoptosis via differing mechanisms in human and mouse tumor cells" . "Truksa, Jaroslav" . "Kov\u00E1\u0159, Jan" . . . "Iron deprivation induces apoptosis via differing mechanisms in human and mouse tumor cells"@en . . "RIV/68378050:_____/04:00105395!RIV/2005/GA0/A23005/N" . "[3A1E54ACA224]" . "0960-7722" . . . . "2"^^ . . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "4"^^ . "Iron deprivation induces apoptosis via differing mechanisms in human and mouse tumor cells"@en . "Iron deprivation induces apoptosis in some cultured tumor cells while other cells are resistant. The aim of the study is to contribute to our understanding of the mechanisms involved in cell death induction by iron deprivation in human tumor cells. We focused on p53 activation and on the mitochondrial pathway of caspase activation. We detected a slight increase in the mitochondrial membrane potential as the only change in sensitive human cells due to iron deprivation. Therefore, we decided to look at the activation of the executioner caspases (caspase-6, caspase-7) and the possible interactions of caspases with their cell inhibitors" . "Nedostatek \u017Eeleza vyvol\u00E1v\u00E1 v lidsk\u00FDch a my\u017E\u00EDch n\u00E1dorov\u00FDch bu\u0148k\u00E1ch apopt\u00F3zu odli\u0161n\u00FDmi mechanismy"@cs . .