. "Storchov\u00E1, Radka" . . "Buckiov\u00E1, Daniela" . "Genetic analysis of X-linked hybrid sterility in the house mouse" . "10"^^ . . "6"^^ . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "X-linked hybrid sterility; genetic analysis"@en . "[B1EDB80C356B]" . "Divina, Petr" . . . "Genetic analysis of X-linked hybrid sterility in the house mouse"@en . . "Genetic analysis of X-linked hybrid sterility in the house mouse" . "Hybrid sterility is a common postzygotic reproductive isolation mechanism, which appears in early stages of speciation of various organisms. Mus musculus musculus and Mus musculus domesticus represent two recently separated mouse subspecies suitable for genetic studies of hybrid sterility. We show that the introgression of Chr X of M. m. musculus origin (PWD/Ph inbred strain) into the genetic background of C57BL/6J inbred strain (predominantly of M. m. domesticus origin) causes male sterility. The X-linked hybrid sterility is associated with reduced testes weight, lower sperm count and morphological abnormalities of sperm heads. The analysis of recombinant ChrXs in sterile and fertile males as well as quantitative trait locus (QTL) analysis of several fertility parameters revealed oligogenic nature of the X-linked hybrid sterility. Mapping and cloning of HstX1 and other genes responsible for sterility of B6-XPWDYB6 males could help to elucidate the role of Chr X in hybrid sterility"@en . "5"^^ . . "Gregorov\u00E1, So\u0148a" . . "P(GA204/02/1373), P(LN00A079), Z(AV0Z5052915)" . . . . . "Kyselov\u00E1, Vendula" . "Hybridn\u00ED sterilita je b\u011B\u017En\u00FD postzygotn\u00ED reproduk\u010Dn\u00ED mechanismus, kter\u00FD se objevuje v \u010Dasn\u00FDch st\u00E1di\u00EDch ur\u010Den\u00ED druhu u r\u016Fzn\u00FDch organism\u016F. Mus musculus musculus a Mus musculus domesticus jsou dva ned\u00E1vno odd\u011Blen\u00E9 poddruhy my\u0161\u00ED vhodn\u00E9 pro genetick\u00E9 studie hybridn\u00ED sterility. Ukazujeme zde, \u017Ee vnesen\u00ED Chr X poch\u00E1zej\u00EDc\u00EDho z M. m. musculus (inbredn\u00ED kmen PWD/Ph) do genetick\u00E9ho z\u00E1kladu inbredn\u00EDho kmene C57BL/6J (poch\u00E1zej\u00EDc\u00EDho p\u0159ev\u00E1\u017En\u011B z M. m. domesticus) zp\u016Fsobuje sterilitu samc\u016F. Hybridn\u00ED sterilita v\u00E1zan\u00E1 na chromozom X je spojena se sn\u00ED\u017Eenou hmotnost\u00ED varlat, ni\u017E\u0161\u00EDm po\u010Dtem spermi\u00ED a morfologick\u00FDmi abnormalitami hlavi\u010Dek spermi\u00ED. Anal\u00FDza rekombinantn\u00EDho Chr X u steriln\u00EDch a fertiln\u00EDch samc\u016F spolu s anal\u00FDzou lokusu kvantitativn\u00EDch znak\u016F (QTL) uk\u00E1zala, \u017Ee hybridn\u00ED sterilita v\u00E1zan\u00E1 na chromozom X je podm\u00EDn\u011Bna v\u00EDce geny. Mapov\u00E1n\u00ED a klonov\u00E1n\u00ED HstX1 a dal\u0161\u00EDch gen\u016F odpov\u011Bdn\u00FDch za sterilitu samc\u016F B6-XPWDYB6 by napomohlo objasnit \u00FAlohu Chr X v hybridn\u00ED sterilit\u011B"@cs . "565324" . "Genetick\u00E1 anal\u00FDza hybridn\u00ED sterility v\u00E1zan\u00E9 na chromozom X u my\u0161i dom\u00E1c\u00ED"@cs . . "RIV/68378050:_____/04:00105334!RIV/2005/AV0/A23005/N" . "0938-8990" . . . . . . "515;524" . . "Hybrid sterility is a common postzygotic reproductive isolation mechanism, which appears in early stages of speciation of various organisms. Mus musculus musculus and Mus musculus domesticus represent two recently separated mouse subspecies suitable for genetic studies of hybrid sterility. We show that the introgression of Chr X of M. m. musculus origin (PWD/Ph inbred strain) into the genetic background of C57BL/6J inbred strain (predominantly of M. m. domesticus origin) causes male sterility. The X-linked hybrid sterility is associated with reduced testes weight, lower sperm count and morphological abnormalities of sperm heads. The analysis of recombinant ChrXs in sterile and fertile males as well as quantitative trait locus (QTL) analysis of several fertility parameters revealed oligogenic nature of the X-linked hybrid sterility. Mapping and cloning of HstX1 and other genes responsible for sterility of B6-XPWDYB6 males could help to elucidate the role of Chr X in hybrid sterility" . "Forejt, Ji\u0159\u00ED" . "Genetick\u00E1 anal\u00FDza hybridn\u00ED sterility v\u00E1zan\u00E9 na chromozom X u my\u0161i dom\u00E1c\u00ED"@cs . "Genetic analysis of X-linked hybrid sterility in the house mouse"@en . "Mammalian Genome" . "-" . "RIV/68378050:_____/04:00105334" . . "15" . .