"7"^^ . . "0007-0920" . . . "And\u011Bra, Ladislav" . "-" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells"@en . . "Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells"@en . "Malign\u00ED mezoteliom (MM) je smrteln\u00FD typ neoplasie se \u0161patnou progn\u00F3zou l\u00E9\u010Dby, zejm\u00E9na d\u00EDky sv\u00E9 odolnosti v\u016F\u010Di apopt\u00F3ze. Studovali jsme apoptotick\u00FD \u00FA\u010Dinek a-tokoferyl sukcin\u00E1tu (a-TOS), siln\u00E9ho proapoptotick\u00E9ho \u010Dinitele, v kombinaci s imunologick\u00FDm proapoptogenem TRAIL (ligand vyvol\u00E1vaj\u00EDc\u00ED apopt\u00F3zu p\u0159ibuzn\u00FD TNF) na bu\u0148ky MM i nemalign\u00ED mezotelov\u00E9 bu\u0148ky, jeliko\u017E bu\u0148ky MM vykazuj\u00ED n\u00EDzkou susceptibilitu ke klinicky zaj\u00EDmav\u00E9mu TRAIL. V\u0161echny testovan\u00E9 linie MM bun\u011Bk byly citliv\u00E9 na apopt\u00F3zu vyvolanou a-TOS a vykazovaly vysokou citlivost na TRAIL v p\u0159\u00EDtomnosti subapoptotick\u00FDch d\u00E1vek analoga vitam\u00EDnu E. Ani TRAIL ani a-TOS, samotn\u00FD \u010Di v kombinaci, nevyvolaly v nemalign\u00EDch mezotelov\u00FDch bu\u0148k\u00E1ch apopt\u00F3zu. Izobologramov\u00E1 anal\u00FDza cytotoxick\u00FDch test\u016F uk\u00E1zala synergistick\u00E9 p\u016Fsoben\u00ED t\u011Bchto dvou \u010Dinidel v MM bu\u0148k\u00E1ch a jejich antagonistick\u00FD \u00FA\u010Dinek v nemalign\u00EDch mezotelov\u00FDch bu\u0148k\u00E1ch. Apopt\u00F3za vyvolan\u00E1 TRAIL a jej\u00ED pos\u00EDlen\u00ED a-TOS byly potla\u010Deny inhibitorem kasp\u00E1zy 8 Z-IETD-FMK a inhibitorem pro v\u0161echn..."@cs . "RIV/68378050:_____/04:00105320!RIV/2005/AV0/A23005/N" . "Malignant mesothelioma (MM) is a fatal type of neoplasia with poor therapeutic prognosis, largely due to resistance to apoptosis. We investigated the apoptotic effect of a-tocopheryl succinate (a-TOS), a strong proapoptotic agent, in combination with the immunological apoptogen TNF-related apoptosis-inducing ligand (TRAIL) on both MM and nonmalignant mesothelial cells, since MM cells show low susceptibility to the clinically intriguing TRAIL. All MM cell lines tested were sensitive to a-TOS-induced apoptosis, and exerted high sensitivity to TRAIL in the presence of subapoptotic doses of the vitamin E analogue. Neither TRAIL or a-TOS alone or in combination caused apoptosis in nonmalignant mesothelial cells. Isobologram analysis of the cytotoxicity assays revealed a synergistic interaction between the two agents in MM cells and their antagonistic effect in nonmalignant mesothelial cells. TRAILinduced apoptosis and its augmentation by a-TOS were inhibited by the caspase-8 inhibitor Z-..." . "1"^^ . . "[F3F495EE0AF8]" . "Rippo, M. R." . "Neu\u017Eil, J." . "Alleva, R." . "Procopio, A." . "Malignant mesothelioma (MM) is a fatal type of neoplasia with poor therapeutic prognosis, largely due to resistance to apoptosis. We investigated the apoptotic effect of a-tocopheryl succinate (a-TOS), a strong proapoptotic agent, in combination with the immunological apoptogen TNF-related apoptosis-inducing ligand (TRAIL) on both MM and nonmalignant mesothelial cells, since MM cells show low susceptibility to the clinically intriguing TRAIL. All MM cell lines tested were sensitive to a-TOS-induced apoptosis, and exerted high sensitivity to TRAIL in the presence of subapoptotic doses of the vitamin E analogue. Neither TRAIL or a-TOS alone or in combination caused apoptosis in nonmalignant mesothelial cells. Isobologram analysis of the cytotoxicity assays revealed a synergistic interaction between the two agents in MM cells and their antagonistic effect in nonmalignant mesothelial cells. TRAILinduced apoptosis and its augmentation by a-TOS were inhibited by the caspase-8 inhibitor Z-..."@en . "Alfa-tokoferyl sukcin\u00E1t a TRAIL selektivn\u011B spolup\u016Fsob\u00ED p\u0159i vyvol\u00E1n\u00ED apopt\u00F3zy u lidsk\u00FDch bun\u011Bk malign\u00EDho mezoteliomu"@cs . "10"^^ . "Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells" . "P(IAA5052001), P(LN00A026), Z(AV0Z5052915)" . . . . . . "1644;1653" . "RIV/68378050:_____/04:00105320" . "Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells" . . "553925" . . . "British Journal of Cancer" . . . "Alfa-tokoferyl sukcin\u00E1t a TRAIL selektivn\u011B spolup\u016Fsob\u00ED p\u0159i vyvol\u00E1n\u00ED apopt\u00F3zy u lidsk\u00FDch bun\u011Bk malign\u00EDho mezoteliomu"@cs . "Moretti, S." . "90" . "TRAiL, a-TOS, apoptosis"@en . . "Tomasetti, M." . . .