. "9"^^ . "Ztr\u00E1ta tumorigenicity my\u0161\u00ED bun\u011B\u010Dn\u00E9 linie karcinomu tlust\u00E9ho st\u0159eva MC38/0 po transdukci retrovirov\u00FDm vektorem nesouc\u00EDm geny pro my\u0161\u00ED IL-12"@cs . "[F33EFBB77110]" . "Mackiewicz, A." . . "Krawczenko, A." . . "8"^^ . . . "Indrov\u00E1, Marie" . . "0015-5500" . "Du\u013D, D." . "Loss of tumorigenicity of murine colon carcinoma MC38/0 cell line after transduction with a retroviral vector carrying murine IL-12 genes" . "Cells of transplantable MC38 colon carcinoma of C57BL/6 mice were adapted to growth in vitro, preserving their tumorigenicity. After transduction with a retroviral vector carrying murine interleukin 12 genes, stable transductant cells were obtained producing IL-12. After subcutaneous inoculation into syngeneic mice, the IL-12-modified cells showed reduced tumorigenicity as compared to parental cells. The obtained results show that the transduced cells could be used both as a model tumour for the study of anticancer immunity and/or as an adjuvant to cancer vaccines" . . "Z(AV0Z5052915)" . "Ztr\u00E1ta tumorigenicity my\u0161\u00ED bun\u011B\u010Dn\u00E9 linie karcinomu tlust\u00E9ho st\u0159eva MC38/0 po transdukci retrovirov\u00FDm vektorem nesouc\u00EDm geny pro my\u0161\u00ED IL-12"@cs . "1" . . . . . "Cells of transplantable MC38 colon carcinoma of C57BL/6 mice were adapted to growth in vitro, preserving their tumorigenicity. After transduction with a retroviral vector carrying murine interleukin 12 genes, stable transductant cells were obtained producing IL-12. After subcutaneous inoculation into syngeneic mice, the IL-12-modified cells showed reduced tumorigenicity as compared to parental cells. The obtained results show that the transduced cells could be used both as a model tumour for the study of anticancer immunity and/or as an adjuvant to cancer vaccines"@en . "Grabarczyk, P." . "Szyda, A." . "Bu\u0148ky transplantovateln\u00E9ho karcinomu tlust\u00E9ho st\u0159eva MC38 my\u0161\u00ED C57BL/6 byly adaptov\u00E1ny pro r\u016Fst in vitro bez ztr\u00E1ty tumorigenicity. Po transdukci retrovirov\u00FDm vektorem nesouc\u00EDm geny pro my\u0161\u00ED IL-12 byly z\u00EDsk\u00E1ny stabiln\u00ED transdukovan\u00E9 bu\u0148ky produkuj\u00EDc\u00ED IL-12. Po subkut\u00E1nn\u00ED inokulaci do syngenn\u00EDch my\u0161\u00ED vykazovaly bu\u0148ky modifikovan\u00E9 IL-12 ve srovn\u00E1n\u00ED s parent\u00E1ln\u00EDmi bu\u0148kami sn\u00ED\u017Eenou tumorigenicitu. Z\u00EDskan\u00E9 v\u00FDsledky ukazuj\u00ED, \u017Ee transdukovan\u00E9 bu\u0148ky bude mo\u017Eno vyu\u017E\u00EDt jako modelov\u00FD n\u00E1dor pro studium protin\u00E1dorov\u00E9 imunity a/nebo jako adjuvans pro n\u00E1dorov\u00E9 vakc\u00EDny"@cs . "1"^^ . "571820" . "Wysocki, P." . . "CZ - \u010Cesk\u00E1 republika" . "Loss of tumorigenicity of murine colon carcinoma MC38/0 cell line after transduction with a retroviral vector carrying murine IL-12 genes"@en . . "Folia Biologica" . "RIV/68378050:_____/04:00105307!RIV/2005/AV0/A23005/N" . "Pajtasz-Piasecka, E." . "RIV/68378050:_____/04:00105307" . . . "50" . "MC38 murine colon carcinoma; IL-12 transduction; tumorigenicity"@en . "Rossowska, J." . "Loss of tumorigenicity of murine colon carcinoma MC38/0 cell line after transduction with a retroviral vector carrying murine IL-12 genes" . "7;14" . "Loss of tumorigenicity of murine colon carcinoma MC38/0 cell line after transduction with a retroviral vector carrying murine IL-12 genes"@en .