. "0008-5472" . . "619644" . "Opposite effects of modifiers of the Apc(Min) mutation in intestine and mammary gland." . . "Piskorowska, J." . . "6"^^ . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Opposite effects of modifiers of the Apc(Min) mutation in intestine and mammary gland."@en . . . "Patterns of tumor susceptibility in different organs are widely divergent in mouse strains: one strain may be highly susceptible to tumors in one organ but resistant in another organ, whereas another strain may exhibit the opposite pattern (P. Demant, Semin. Cancer Biol., 3: 159-166, 1992). Therefore, susceptibility to tumors in different organs is assumed to be controlled by different sets of genes. On the other hand, many oncogenes and tumor suppressor genes are mutated in tumors from different organs, indicating that similar tumorigenic pathways operate in various tissues. To obtain insight into the interactions of susceptibility genes with one of such pathways, we compared tumorigenesis in intestine and mammary gland in recombinant congenic strains (RCSs) carrying the Apc(Min) mutation, affecting the Writ pathway. The presence of Apc(Min) increased considerably the incidence of intestinal and mammary tumors. The individual RCSs differed in the number and latency of Apc(Min)-induced intestinal and"@en . "2003" . . . "Opposite effects of modifiers of the Apc(Min) mutation in intestine and mammary gland." . . . "Z(AV0Z5052915)" . "Patterns of tumor susceptibility in different organs are widely divergent in mouse strains: one strain may be highly susceptible to tumors in one organ but resistant in another organ, whereas another strain may exhibit the opposite pattern (P. Demant, Semin. Cancer Biol., 3: 159-166, 1992). Therefore, susceptibility to tumors in different organs is assumed to be controlled by different sets of genes. On the other hand, many oncogenes and tumor suppressor genes are mutated in tumors from different organs, indicating that similar tumorigenic pathways operate in various tissues. To obtain insight into the interactions of susceptibility genes with one of such pathways, we compared tumorigenesis in intestine and mammary gland in recombinant congenic strains (RCSs) carrying the Apc(Min) mutation, affecting the Writ pathway. The presence of Apc(Min) increased considerably the incidence of intestinal and mammary tumors. The individual RCSs differed in the number and latency of Apc(Min)-induced intestinal and" . "RIV/68378050:_____/03:23033200!RIV/2004/AV0/A23004/N" . "1"^^ . . . . "[9A17A1DA6034]" . "0"^^ . "0"^^ . "Opposite effects of modifiers of the Apc(Min) mutation in intestine and mammary gland."@en . "Pil\u010D\u00EDk, Tom\u00E1\u0161" . "Krysiak, E." . . "5"^^ . "4533;4537" . "Cancer research" . "Sitarz, M." . "Czarnomska, A." . "RIV/68378050:_____/03:23033200" . "63" . "Recombinant congenic strains; primary breast cancers; APC gene"@en . "Demant, P." .