. "21" . "Vaccine" . "V-src oncogene-specific carboxy-terminal peptide is immunoprotective against Rous sarcoma growth in chickens with MHC class I allele B-F12." . . . "Z(AV0Z5052915)" . "6"^^ . "0"^^ . "0"^^ . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "1"^^ . "Hunt, L." . "H\u00E1la, K." . "0264-410X" . "[E8222210B0DD]" . "RIV/68378050:_____/03:23033188" . . . "V-src oncogene-specific carboxy-terminal peptide is immunoprotective against Rous sarcoma growth in chickens with MHC class I allele B-F12."@en . . "5"^^ . . . "633886" . . . "B-12 haplotype of the inbred chicken line CB (B-12/B-12) contains, like the bulk of chicken MHC(B) haplotypes, only a single dominantly expressed class I molecule (B-F). The peptide binding motifs for this major B-F12-molecule, in chickens of Rous sarcoma regressor line CB (B-12/B-12) have been determined. Using stringent and relaxed motifs, several peptides were found in the v-src molecule of the PR-RSV-C, but most of these peptides are identical with that of endogenous c-src. Only the v-src C-tail peptide(517-524) (LPACVLEV) contains critical anchor amino acids (valine at positions 5 and 8) and shows a sequence different from the corresponding c-src peptide. This v-src C-tail peptide up-regulates expression of the B-F12 class I molecule on PBL, as assessed by FACS analysis, and stimulates T cell proliferation in a [H-3]thymidine uptake assay. A protective effect of the immune response to LPACVLEV against RSV challenge was demonstrated in CB (B-12/B-12) chickens immunised with peptides encapsulated i"@en . "RIV/68378050:_____/03:23033188!RIV/2004/AV0/A23004/N" . "2003" . . "4694;4699" . "B-12 haplotype of the inbred chicken line CB (B-12/B-12) contains, like the bulk of chicken MHC(B) haplotypes, only a single dominantly expressed class I molecule (B-F). The peptide binding motifs for this major B-F12-molecule, in chickens of Rous sarcoma regressor line CB (B-12/B-12) have been determined. Using stringent and relaxed motifs, several peptides were found in the v-src molecule of the PR-RSV-C, but most of these peptides are identical with that of endogenous c-src. Only the v-src C-tail peptide(517-524) (LPACVLEV) contains critical anchor amino acids (valine at positions 5 and 8) and shows a sequence different from the corresponding c-src peptide. This v-src C-tail peptide up-regulates expression of the B-F12 class I molecule on PBL, as assessed by FACS analysis, and stimulates T cell proliferation in a [H-3]thymidine uptake assay. A protective effect of the immune response to LPACVLEV against RSV challenge was demonstrated in CB (B-12/B-12) chickens immunised with peptides encapsulated i" . "V-src oncogene-specific carboxy-terminal peptide is immunoprotective against Rous sarcoma growth in chickens with MHC class I allele B-F12."@en . "Hofmann, A." . "Plach\u00FD, Ji\u0159\u00ED" . . "Kaufman, J." . . "Rous sarcoma; v-src peptide; chicken MHC class I allele"@en . . "V-src oncogene-specific carboxy-terminal peptide is immunoprotective against Rous sarcoma growth in chickens with MHC class I allele B-F12." .