"602045" . "Constitutive excluslion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes." . "[70393C6346AF]" . . . . "Constitutive excluslion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes."@en . . "0006-4971" . "Ho\u0159ej\u0161\u00ED, V\u00E1clav" . "P(LN00A026), Z(AV0Z5052915)" . "RIV/68378050:_____/03:23033105!RIV/2004/AV0/A23004/N" . . "7"^^ . "Langsley, G." . . . "Mooney, N." . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "101" . "Transformed phenotype of B cells infected with Theileria parva reverts on drug-induced parasite death, and the cured lymphocytes acquire a resting phenotype. Lymphocyte proliferation and activation of the transcription factor AP-1 are mediated by Src-family protein tyrosine kinases (present in membrane microdomains, GEMs) in a parasite-dependent fashion. Src-family PTKs are negatively regulated by PTK Csk complexed to tyrosine-photosphorylated transmembrane adapter protein PAG. Proliferation arrest led to a striking increase of PAG/Cbp in GEMs increased markedly, whereas PTK Hck accumulation in GEM fractions did not alter on growth arrest. Thus, Theileria-induced lymphocyte proliferation and permanent activation of Hck may stem from down-regulation of PAG/Cbp and the concomitant constitutive loss of the negative regulator Csk from the GEMs of transformed B cells."@en . . . "Theileriosis; transformation; Csk"@en . "Baumgartner, M." . "8"^^ . . "Angelisov\u00E1, Pavla" . "Werling, D." . "Constitutive excluslion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes." . "1874;1881" . . "Blood" . . . "2"^^ . . . "Transformed phenotype of B cells infected with Theileria parva reverts on drug-induced parasite death, and the cured lymphocytes acquire a resting phenotype. Lymphocyte proliferation and activation of the transcription factor AP-1 are mediated by Src-family protein tyrosine kinases (present in membrane microdomains, GEMs) in a parasite-dependent fashion. Src-family PTKs are negatively regulated by PTK Csk complexed to tyrosine-photosphorylated transmembrane adapter protein PAG. Proliferation arrest led to a striking increase of PAG/Cbp in GEMs increased markedly, whereas PTK Hck accumulation in GEM fractions did not alter on growth arrest. Thus, Theileria-induced lymphocyte proliferation and permanent activation of Hck may stem from down-regulation of PAG/Cbp and the concomitant constitutive loss of the negative regulator Csk from the GEMs of transformed B cells." . . "Constitutive excluslion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes."@en . "5" . "0"^^ . "Setterblad, N." . "0"^^ . . . "RIV/68378050:_____/03:23033105" .