. . "1"^^ . "\u0160toura\u010Dov\u00E1, Renata" . "70" . "Crystallographic study of an anti=carbonic anhydrase IX monoclonal antibody M75."@en . . "RIV/68378050:_____/03:23033033" . "2003-03-13+01:00"^^ . . "8"^^ . "Material Structure in Chemistry, Biology, Physics and Technology." . . "RIV/68378050:_____/03:23033033!RIV/2004/AV0/A23004/N" . "F\u00E1bry, Milan" . . "Crystallographic study of an anti=carbonic anhydrase IX monoclonal antibody M75." . "9"^^ . . "Z\u00E1vada, Jan" . "602450" . . . "Z(AV0Z5052915)" . "Czech and Slovak Crystallographic Association" . "Z\u00E1vadov\u00E1, Zuzana" . . "Praha, \u010Cesk\u00E1 republika" . . . "[E49B423F6E4A]" . "Pastorekov\u00E1, S." . "Ho\u0159ej\u0161\u00ED, Magda" . . "Crystallographic study of an anti=carbonic anhydrase IX monoclonal antibody M75." . "Brynda, Ji\u0159\u00ED" . . . . "Carbonic anhydrase IX (CA IX) is a cell surface protein, strongly associated with certain types of human carcinomas. Structural study of a CA IX-binding monoclonal antibody (mAb) M75, complexed with its epitope peptide may contribute toward elucidation of the role of CA IX. Monoclonal antibody M75 was obtained and proved to react excellently with native and denaturated CA IX. Using synthetic oligopeptides, the epitope of mAb M75 was localized in the proteoglycan domain of CA IX, in the region of a tandem repeat and identified as amino acids PGEEDLP. The Fab fragment was obtained by papain cleavage. We obtained crystals of free Fab M75 and Fab M75 complexed with two different epitope peptides. The data set for Fab M75 was collected and the structure solving is underway." . . . . . . "Nov\u00E9 Hrady [CZ]" . "Kr\u00E1l, Vlastimil" . "Crystallographic study of an anti=carbonic anhydrase IX monoclonal antibody M75."@en . "anti-carbonic ahydrase antibody, cancer, crystallization"@en . . . "Carbonic anhydrase IX (CA IX) is a cell surface protein, strongly associated with certain types of human carcinomas. Structural study of a CA IX-binding monoclonal antibody (mAb) M75, complexed with its epitope peptide may contribute toward elucidation of the role of CA IX. Monoclonal antibody M75 was obtained and proved to react excellently with native and denaturated CA IX. Using synthetic oligopeptides, the epitope of mAb M75 was localized in the proteoglycan domain of CA IX, in the region of a tandem repeat and identified as amino acids PGEEDLP. The Fab fragment was obtained by papain cleavage. We obtained crystals of free Fab M75 and Fab M75 complexed with two different epitope peptides. The data set for Fab M75 was collected and the structure solving is underway."@en . "0"^^ . "Sedl\u00E1\u010Dek, Juraj" . "0"^^ .