"Lescar, J." . . "RIV/68378050:_____/03:00108977" . "Immunoglobulin"@en . . "0907-4449" . . . . "Monoklon\u00E1ln\u00ED protil\u00E1tka 1696, kter\u00E1 byla p\u0159ipravena proti prote\u00E1ze HIV-1, potla\u010Duje katalytickou aktivitu enzymu z obou kmen\u016F HIV-1 i HIV-2. Tato protil\u00E1tka k\u0159\u00ED\u017Eov\u011B reaguje s peptidy obsahuj\u00EDc\u00ED N-konec enzymu, kter\u00FD je mezi t\u011Bmito dv\u011Bma kmeny vysoce konzervov\u00E1n. Je pops\u00E1na krystalov\u00E1 struktura jedno\u0159et\u011Bzcov\u00E9ho fragmentu Fv d\u0159\u00EDve popsan\u00E9ho nekomplexovan\u00E9ho Fab-1696 a struktur scFv-1696 v\u00E1zan\u00FDch na protil\u00E1tku. Jsou pozorov\u00E1ny rozs\u00E1hl\u00E9 konforma\u010Dn\u00ED zm\u011Bny ve t\u0159et\u00ED hypervariabiln\u00ED oblasti t\u011B\u017Ek\u00E9ho \u0159et\u011Bzce a rozd\u00EDly v relativn\u00ED orientaci variabiln\u00EDch dom\u00E9n u t\u011Bchto r\u016Fzn\u00FDch struktur"@cs . . . . "Brynda, Ji\u0159\u00ED" . . "DK - D\u00E1nsk\u00E9 kr\u00E1lovstv\u00ED" . "Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases"@en . "Part 5" . "955;957" . "Sedl\u00E1\u010Dek, Juraj" . . "RIV/68378050:_____/03:00108977!RIV/2005/AV0/A23005/N" . . . "629257" . . "3"^^ . . "The monoclonal antibody 1696, which was raised against the HIV-1 protease, inhibits the catalytic activity of the enzyme from both the HIV-1 and HIV-2 strains. The antibody cross-reacts with peptides containing the N-terminus of the enzyme, which is highly conserved between these strains. The crystal structure of a single-chain Fv fragment of the previously reported non-complexed Fab-1696 and antigen-bound scFv-1696 structures. Large conformational changes in the third hypervariable region of the heavy chain and differences in relative orientation of the variable domains are observed between the different structures" . . "Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases" . "Struktura jedno\u0159et\u011Bzcov\u00E9ho fragmentu Fv, kter\u00FD inhibuje prote\u00E1zy HIV-1 a HIV-2"@cs . "[44D45C17AF54]" . "\u0158ez\u00E1\u010Dov\u00E1, Pavl\u00EDna" . "53" . . "Ho\u0159ej\u0161\u00ED, Magdalena" . "Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases" . "The monoclonal antibody 1696, which was raised against the HIV-1 protease, inhibits the catalytic activity of the enzyme from both the HIV-1 and HIV-2 strains. The antibody cross-reacts with peptides containing the N-terminus of the enzyme, which is highly conserved between these strains. The crystal structure of a single-chain Fv fragment of the previously reported non-complexed Fab-1696 and antigen-bound scFv-1696 structures. Large conformational changes in the third hypervariable region of the heavy chain and differences in relative orientation of the variable domains are observed between the different structures"@en . "Bentley, G. A." . . "Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases"@en . "P(GV203/98/K023), Z(AV0Z5052915)" . "Struktura jedno\u0159et\u011Bzcov\u00E9ho fragmentu Fv, kter\u00FD inhibuje prote\u00E1zy HIV-1 a HIV-2"@cs . "F\u00E1bry, Milan" . "5"^^ . . "7"^^ . . "Acta Crystallographica Section D-Biological Crystallography" .