. "RIV/68378050:_____/02:23033137" . . . . . "638729" . . . . "Kov\u00E1\u0159, Jan" . "2002-10-24+02:00"^^ . "UK" . . . "Truksa, Jaroslav" . "Ehrlichov\u00E1, Marie" . "0"^^ . . . "Iron deprivation specifically induces apoptosis in some tumor cells while other tumor cells are resistant. We have shown previously that the p53 pathway, including p53 activation and subsequent regulation of the expression of relevant genes of the bcl-2 family such as bax and bcl-2, is not involved in apoptosis induction by iron deprivation. In the present study we compared the activity of caspase-3 and caspase-9 in sensitive (38C13) versus resistant (EL4) cells under control and iron-depriving conditions. Iron deprivation resulted in a significant increase of the caspase-3 activity in sensitive but not in resistant cells. Similarly, we detected caspase-9 activation under iron deprivation in sensitive but not in resistant cells. We also compared the distribution of some proteins of the Bcl-2 family in sensitive versus resistant cells under control and iron-depriving conditions. Confocal microscopy revealed that iron deprivation resulted in Bax protein translocation from the cytosol to mitochondria in" . . "0"^^ . "Iron deprivation specifically induces apoptosis in some tumor cells while other tumor cells are resistant. We have shown previously that the p53 pathway, including p53 activation and subsequent regulation of the expression of relevant genes of the bcl-2 family such as bax and bcl-2, is not involved in apoptosis induction by iron deprivation. In the present study we compared the activity of caspase-3 and caspase-9 in sensitive (38C13) versus resistant (EL4) cells under control and iron-depriving conditions. Iron deprivation resulted in a significant increase of the caspase-3 activity in sensitive but not in resistant cells. Similarly, we detected caspase-9 activation under iron deprivation in sensitive but not in resistant cells. We also compared the distribution of some proteins of the Bcl-2 family in sensitive versus resistant cells under control and iron-depriving conditions. Confocal microscopy revealed that iron deprivation resulted in Bax protein translocation from the cytosol to mitochondria in"@en . . "Z(AV0Z5052915)" . "2" . . "Blackwell Publishing" . "Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases."@en . "5"^^ . "RIV/68378050:_____/02:23033137!RIV/2004/AV0/A23004/N" . "Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases." . . . . "\u0160t\u00FDbrov\u00E1, Hana" . "5"^^ . "Koc, Michal" . "Abstracts of the 25th Meeting of the European Study Group for Cell Proliferation (ESGCP)." . "apoptosis induction; caspase activation; Bax translocation"@en . "2"^^ . "Reims [FR]" . "Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases." . . "[0D63A8D866BB]" . "Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases."@en . .