"Krulov\u00E1, Magdalena" . . . "Svobodov\u00E1, M." . . . "54" . "Mouse genetic model for clinical and immunological heterogeneity of leishmaniasis" . . "10"^^ . "654336" . "0093-7711" . "RIV/68378050:_____/02:00109012" . . "Badalov\u00E1, Jana" . . . "My\u0161\u00ED genetick\u00FD model pro klinickou a imunologickou heterogenitu leishmaniasis"@cs . . . "Hart, A. A. M." . . "3" . "Systematic assessment of the role of host genes in clinico-pathological and immunological manifestations of Leishmania major-induced disease in mice was performed using 20 recombinant congenic (RC) strains. As the RC strains are homozygous and each carries a different, random set of 12.5% genes from the resistant strain, STS/A, and 87.5% genes from the susceptible strain, BALB/cHeA, they allowed us to study the pathological and immunological characteristics of infected hosts in 20 fixed different random combinations of BALB/c and STS genes. The 20 RC strains differ widely in expression of different symptoms of disease and in immunological characteristics. Disease or healing in different strains occurred in association with different components of immune response -- with the exception of a frequently occurring correlation between the disease and IgE levels. Moreover, some parameters of the immune response were highly correlated in some strains but not at all in others. This shows tha..."@en . . . . . "Systematic assessment of the role of host genes in clinico-pathological and immunological manifestations of Leishmania major-induced disease in mice was performed using 20 recombinant congenic (RC) strains. As the RC strains are homozygous and each carries a different, random set of 12.5% genes from the resistant strain, STS/A, and 87.5% genes from the susceptible strain, BALB/cHeA, they allowed us to study the pathological and immunological characteristics of infected hosts in 20 fixed different random combinations of BALB/c and STS genes. The 20 RC strains differ widely in expression of different symptoms of disease and in immunological characteristics. Disease or healing in different strains occurred in association with different components of immune response -- with the exception of a frequently occurring correlation between the disease and IgE levels. Moreover, some parameters of the immune response were highly correlated in some strains but not at all in others. This shows tha..." . "Havelkov\u00E1, Helena" . "Lipoldov\u00E1, Marie" . . "Schlegel, David" . "174;183" . "Volf, P." . . . . . "My\u0161\u00ED genetick\u00FD model pro klinickou a imunologickou heterogenitu leishmaniasis"@cs . "P(GA310/00/0760), P(NM28), P(OK 349), P(OK 394), Z(AV0Z5052915), Z(MSM 113100004)" . "S vyu\u017Eit\u00EDm 20 rekombinantn\u00EDch kongenn\u00EDch (RC) kmen\u016F my\u0161\u00ED bylo provedeno systematick\u00E9 zhodnocen\u00ED \u00FAlohy hostitelsk\u00FDch gen\u016F v klinicko-patologick\u00FDch a imunologick\u00FDch projevech onemocn\u011Bn\u00ED my\u0161\u00ED zp\u016Fsoben\u00E9ho Leishmania major. Jeliko\u017E kmeny RC jsou homozygotn\u00ED a ka\u017Ed\u00FD z nich obsahuje odli\u0161n\u00FD, n\u00E1hodn\u00FD soubor 12,5% gen\u016F z odoln\u00E9ho kmene STS/A a 87,5% gen\u016F z citliv\u00E9ho kmene BALB/cHeA, mohli jsme d\u00EDky nim studovat patologick\u00E9 a imunologick\u00E9 charakteristiky infikovan\u00FDch hostitel\u016F ve 20 st\u00E1l\u00FDch odli\u0161n\u00FDch n\u00E1hodn\u00FDch kombinac\u00EDch gen\u016F BALB/c a STS. Dan\u00FDch 20 RC kmen\u016F se velmi li\u0161\u00ED v expresi r\u016Fzn\u00FDch symptom\u016F choroby a v imunologick\u00FDch charakteristik\u00E1ch. Onemocn\u011Bn\u00ED \u010Di uzdraven\u00ED prob\u00EDhalo v r\u016Fzn\u00FDch kmenech ve spojen\u00ED s r\u016Fzn\u00FDmi slo\u017Ekami imunitn\u00ED odpov\u011Bdi - s v\u00FDjimkou \u010Dasto se vyskytuj\u00EDc\u00ED korelace mezi chorobou a hladinami IgE. Nav\u00EDc ur\u010Dit\u00E9 parametry imunitn\u00ED odpov\u011Bdi v n\u011Bkter\u00FDch kmenech velmi dob\u0159e souhlasily, ale v jin\u00FDch ne. Z toho vypl\u00FDv\u00E1, \u017Ee \u0159ada sch\u00E9mat imunitn\u00ED odpov\u011Bdi m\u016F\u017Ee b\u00FDt spojena se stejn\u00FDm ..."@cs . "5"^^ . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "Mouse genetic model for clinical and immunological heterogeneity of leishmaniasis"@en . . "Leishmaniasis; mouse model; complex disease"@en . "RIV/68378050:_____/02:00109012!RIV/2005/AV0/A23005/N" . "Immunogenetics" . "Demant, P." . . "[85BE63760B68]" . "10"^^ . "Mouse genetic model for clinical and immunological heterogeneity of leishmaniasis" . . "Noh\u00FDnkov\u00E1, E." . . "Mouse genetic model for clinical and immunological heterogeneity of leishmaniasis"@en . .