. "Beskid, Olena" . . "L\u00EDbalov\u00E1, Helena" . . "Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis" . "000336694800004" . . "10.1016/j.mrfmmm.2014.03.006" . . . "Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants" . "[8002F4CE3E82]" . "MAY-JUN 2014" . "I, P(GAP503/11/0084)" . . . . "RIV/68378041:_____/14:00435644!RIV15-GA0-68378041" . "Beskid, Olena" . "\u0160r\u00E1m, Radim" . "RIV/68378041:_____/14:00435644" . . "The cells were treated for 24 h with B[a]P (1 \u03BCM, 10 \u03BCM, 25 \u03BCM) and EOMs (1 \u03BCg/ml, 10 \u03BCg/ml, 25 \u03BCg/ml). 25 \u03BCM of B[a]P and most of the tested doses of EOMs induced double strand breaks (DSBs) as indicated by H2AX phosphorylation. DNA damage was accompanied by induction of XRCC4 expression and an increased frequency of chromosomal aberrations. Translocations most frequently affected chromosome 7. We observed only a weak induction of Ku70/80 expression as well as ligation activity of nuclear extracts."@en . "Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants"@en . . . . . "R\u00F6ssner ml., Pavel" . "0027-5107" . . "benzo[a]pyrene; chromosome aberrations; double-strand DNA breaks"@en . . . "Topinka, Jan" . . "Tabashidze, Nana" . . "763-764" . "32758" . . . "Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants" . "8"^^ . "NL - Nizozemsko" . "11"^^ . "Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants"@en . "8"^^ . "The cells were treated for 24 h with B[a]P (1 \u03BCM, 10 \u03BCM, 25 \u03BCM) and EOMs (1 \u03BCg/ml, 10 \u03BCg/ml, 25 \u03BCg/ml). 25 \u03BCM of B[a]P and most of the tested doses of EOMs induced double strand breaks (DSBs) as indicated by H2AX phosphorylation. DNA damage was accompanied by induction of XRCC4 expression and an increased frequency of chromosomal aberrations. Translocations most frequently affected chromosome 7. We observed only a weak induction of Ku70/80 expression as well as ligation activity of nuclear extracts." . "R\u00F6ssnerov\u00E1, Andrea" . "Uhl\u00ED\u0159ov\u00E1, Kate\u0159ina" . "Tabashidze, Nana" .