. . . "000342614300008" . . "The aim of this study was to investigate the effects of systemically administered bone-marrow-derived mesenchymal stromal cells (MSCs) on the early acute phase of inflammation in the alkali-burned eye. Mice with damaged eyes were either untreated or treated 24?h after the injury with an intravenous administration of fluorescent-dye-labeled MSCs that were unstimulated or pretreated with interleukin-1\u03B1 (IL-1\u03B1), transforming growth factor-\u03B2 (TGF-\u03B2), or interferon-\u03B3 (IFN-\u03B3). Analysis of cell suspensions prepared from the eyes of treated mice on day 3 after the alkali burn revealed that MSCs specifically migrated to the damaged eye and that the number of labeled MSCs was more than 30-times higher in damaged eyes compared with control eyes. The study of the composition of the leukocyte populations within the damaged eyes showed that all types of tested MSCs slightly decreased the number of infiltrating lymphoid and myeloid cells, but only MSCs pretreated with IFN-\u03B3 significantly decreased the percentage of eye-infiltrating cells with a more profound effect on myeloid cells."@en . "11"^^ . "Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-\u03B3-Treated Mesenchymal Stromal Cells" . "20" . . "5"^^ . . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-\u03B3-Treated Mesenchymal Stromal Cells"@en . . "10.1089/scd.2013.0568" . . . "23" . "Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-\u03B3-Treated Mesenchymal Stromal Cells"@en . "6"^^ . . . "RIV/68378041:_____/14:00432995" . "mesenchymal stromal cells; nitric oxide; transforming growth factor beta"@en . "Zaj\u00EDcov\u00E1, Alena" . "[4469738F7909]" . . "Krulov\u00E1, Magdal\u00E9na" . . "Javorkov\u00E1, Eli\u0161ka" . . "I, P(GA14-12580S), P(GAP301/11/1568), P(GAP304/11/0653)" . . "Tro\u0161an, Peter" . "Stem Cells and Development" . "H\u00E1jkov\u00E1, M." . . . "1547-3287" . "Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-\u03B3-Treated Mesenchymal Stromal Cells" . . "RIV/68378041:_____/14:00432995!RIV15-GA0-68378041" . . . "The aim of this study was to investigate the effects of systemically administered bone-marrow-derived mesenchymal stromal cells (MSCs) on the early acute phase of inflammation in the alkali-burned eye. Mice with damaged eyes were either untreated or treated 24?h after the injury with an intravenous administration of fluorescent-dye-labeled MSCs that were unstimulated or pretreated with interleukin-1\u03B1 (IL-1\u03B1), transforming growth factor-\u03B2 (TGF-\u03B2), or interferon-\u03B3 (IFN-\u03B3). Analysis of cell suspensions prepared from the eyes of treated mice on day 3 after the alkali burn revealed that MSCs specifically migrated to the damaged eye and that the number of labeled MSCs was more than 30-times higher in damaged eyes compared with control eyes. The study of the composition of the leukocyte populations within the damaged eyes showed that all types of tested MSCs slightly decreased the number of infiltrating lymphoid and myeloid cells, but only MSCs pretreated with IFN-\u03B3 significantly decreased the percentage of eye-infiltrating cells with a more profound effect on myeloid cells." . "Hol\u00E1\u0148, Vladim\u00EDr" . . "30225" .