"[CFF08D519841]" . . "Hovo\u0159\u00E1kov\u00E1, M\u00E1ria" . "RIV/68378041:_____/11:00364583!RIV12-AV0-68378041" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . . "Charles, C." . . . . "Jheon, A." . "P(GA304/07/0223), P(GA304/09/1579), S, Z(AV0Z50390512), Z(MSM0021620843)" . "In Sprouty loss of function mutants, splitting of gene expression domains and reduced apoptosis was associated with subdivision of the incisor primordium and a multiplication of its stem cell-containing regions. The changes in Sprouty gene dosage led to a graded change in incisor number, with progressive decreases in Sprouty dosage leading to increasing numbers of teeth. The independent development of two incisors in mutants with large decreases in Sprouty dosage mimicked the likely condition of rodent ancestors. Our findings indicate that altering genetic dosage of an antagonist can recapitulate ancestral dental characters, and that tooth number can be progressively regulated by changing levels of activity of a single signal transduction pathway." . . "Viriot, L." . "Lyons, D. B." . "Lesot, H." . "3"^^ . "Ahn, Y." . "Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling"@en . "11"^^ . . "Development" . "Churav\u00E1, Svatava" . . "FGF signaling; Sprouty genes; Incisor"@en . . "226280" . "Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling"@en . "Biehs, B." . "Klein, O. D." . "Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling" . . "000294156000021" . "14"^^ . "Peterkov\u00E1, Renata" . "Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling" . "10.1242/dev.069195" . "RIV/68378041:_____/11:00364583" . . . . . "0950-1991" . "138" . . . "Marangoni, P." . "Balooch, G." . . "Krumlauf, R." . "In Sprouty loss of function mutants, splitting of gene expression domains and reduced apoptosis was associated with subdivision of the incisor primordium and a multiplication of its stem cell-containing regions. The changes in Sprouty gene dosage led to a graded change in incisor number, with progressive decreases in Sprouty dosage leading to increasing numbers of teeth. The independent development of two incisors in mutants with large decreases in Sprouty dosage mimicked the likely condition of rodent ancestors. Our findings indicate that altering genetic dosage of an antagonist can recapitulate ancestral dental characters, and that tooth number can be progressively regulated by changing levels of activity of a single signal transduction pathway."@en . . . "18" . .