. "-" . . . . "Increased cytosolic calcium ([Ca2+]i) and nitric oxide (NO) are associated with apoptosis that is a main feature of many liver diseases and is characterized by biochemical and morphological features. Our data suggest that the extent of the [Ca2+]i increase and the modulation of NO production due to thapsigargin treatment contribute to hepatocyte apoptotic and/or necrotic events." . "[670B403CFB50]" . "23" . . . "18"^^ . . . . . "Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture."@en . "2"^^ . "Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture." . "Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture." . "Increased cytosolic calcium ([Ca2+]i) and nitric oxide (NO) are associated with apoptosis that is a main feature of many liver diseases and is characterized by biochemical and morphological features. Our data suggest that the extent of the [Ca2+]i increase and the modulation of NO production due to thapsigargin treatment contribute to hepatocyte apoptotic and/or necrotic events."@en . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Mart\u00EDnek, J." . "P(GA305/05/2425), P(GA305/07/0061), Z(AV0Z50390512), Z(MSM0021620807)" . . . "Apoptosis; Intracellular free calcium; Necrosis"@en . "Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture."@en . "5"^^ . . "Farghali, H." . "RIV/68378041:_____/07:00098472!RIV08-AV0-68378041" . "0742-2091" . . "Kutinov\u00E1-Canov\u00E1, N." . . "RIV/68378041:_____/07:00098472" . . "Thapsigargin, selektivn\u00ED inhibitor Ca2+-ATPas sarko-endoplasmatick\u00E9ho retikula, moduluje produkci oxidu dusnat\u00E9ho a smrt kultivovan\u00FDch jatern\u00EDch hepatocyt\u016F potkan\u016F."@cs . "337;354" . "Cell Biology and Toxicology" . . "Zv\u00FD\u0161en\u00E1 koncentrace intracelul\u00E1rn\u00EDho v\u00E1pn\u00EDku a oxidu dusnat\u00E9ho je spojen\u00E1 s apopt\u00F3zou, kter\u00E1 charakterizuje mnoho jatern\u00EDch onemocn\u011Bn\u00ED, doprov\u00E1zen\u00FDch biochemick\u00FDmi a biochemick\u00FDmi zm\u011Bnami. Zjistili jsme, \u017Ee zv\u00FD\u0161en\u00ED intracelul\u00E1rn\u00EDho v\u00E1pn\u00EDku a modulaci produkce oxidu dusnat\u00E9ho je mo\u017En\u00E9 pova\u017Eovat za faktory, kter\u00E9 p\u0159isp\u00EDvaj\u00ED k apopt\u00F3ze a/nebo nekr\u00F3ze hepatocyt\u016F."@cs . "454960" . "Thapsigargin, selektivn\u00ED inhibitor Ca2+-ATPas sarko-endoplasmatick\u00E9ho retikula, moduluje produkci oxidu dusnat\u00E9ho a smrt kultivovan\u00FDch jatern\u00EDch hepatocyt\u016F potkan\u016F."@cs . . "Kmon\u00ED\u010Dkov\u00E1, Eva" . "Z\u00EDdek, Zden\u011Bk" . . .