. . . "RIV/68378041:_____/02:19023087" . "Farka\u0161, R." . "1"^^ . "programmed cell death; BR-C transcription factors; drosophila"@en . "67;78" . "Journal of Structural Biology" . . "1047-8477" . "[C4382E770188]" . . "Ra\u0161ka, Ivan" . "4"^^ . . . "0"^^ . "0"^^ . . "666580" . "Mechler, B. M." . "140" . "P(GA304/02/0342), Z(AV0Z5039906), Z(MSM 111100003)" . . "N/A" . "The destruction of obsolete larval tissues at the onset of insect metamorphosis is a complex process triggered by the steroid hormone ecdysone. The reduced bristels on palpus (rbp) gene of the Broad-Complex (BR-C) locus plays a critical role in salivary gland (SG) degeneration. The BR-C locus encodes four major protein isoforms, including BR-C Z1, Z2, Z3, and Z4. We used transgenes expressing each of the four major BR-C isoform proteins and revealed that, depending upon the period of expression relative to the major peak of ecdysone production, BR-C Z1, Z2,and Z4 first inhibited and then stimulated the process of SG degeneration. In contrast, BR-C Z3 exerted all time points an inhibition on SG degeneration."@en . "Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors." . . "Kuch\u00E1rov\u00E1-Mahmood, S." . "Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors." . . . . . "12"^^ . . "Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors."@en . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "RIV/68378041:_____/02:19023087!RIV/2003/GA0/A19003/N" . . . . "Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors."@en . "The destruction of obsolete larval tissues at the onset of insect metamorphosis is a complex process triggered by the steroid hormone ecdysone. The reduced bristels on palpus (rbp) gene of the Broad-Complex (BR-C) locus plays a critical role in salivary gland (SG) degeneration. The BR-C locus encodes four major protein isoforms, including BR-C Z1, Z2, Z3, and Z4. We used transgenes expressing each of the four major BR-C isoform proteins and revealed that, depending upon the period of expression relative to the major peak of ecdysone production, BR-C Z1, Z2,and Z4 first inhibited and then stimulated the process of SG degeneration. In contrast, BR-C Z3 exerted all time points an inhibition on SG degeneration." .