"Bryja, Josef" . . . "000289713700005" . . . "14"^^ . . . . . . . "Heredity" . "201006" . . . "Pi\u00E1lek, Jaroslav" . "RIV/68081766:_____/11:00347205!RIV12-AV0-68081766" . "Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations"@en . . "Baird, S. J. E." . "10.1038/hdy.2010.112" . "MHC; house mouse; selection; population structure; trans-species polymorphism"@en . "P(GA206/08/0640), P(IAA600930608), Z(AV0Z60930519)" . . . "106" . . . "5"^^ . . "5" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "The mammalian major histocompatibility complex (MHC) is a tightly linked cluster of immune genes, and is often thought of as inherited as a unit. This has led to the hope that studying a single MHC gene will reveal patterns of evolution representative of the MHC as a whole. In this study we analyse a 1000-km transect of MHC variation in house mice to compare signals of selection and patterns of diversification at two closely linked MHC class II genes, H-2Aa and H-2Eb. We show that although they are 0.01cM apart, disparate evolutionary patterns were detected. H-2Aa shows higher allelic polymorphism, faster allelic turnover due to higher mutation rates, stronger positive selection at antigen-binding sites and higher population structuring than H-2Eb. H-2Eb alleles are maintained in the gene pool for longer, including over separation of the subspecies, some H-2Eb alleles are positively and others negatively selected and some of the alleles are not expressed."@en . "Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations" . "Go\u00FCy de Bellocq, J." . . "[39D289509B67]" . "RIV/68081766:_____/11:00347205" . "Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations"@en . "0018-067X" . "3"^^ . "Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations" . "The mammalian major histocompatibility complex (MHC) is a tightly linked cluster of immune genes, and is often thought of as inherited as a unit. This has led to the hope that studying a single MHC gene will reveal patterns of evolution representative of the MHC as a whole. In this study we analyse a 1000-km transect of MHC variation in house mice to compare signals of selection and patterns of diversification at two closely linked MHC class II genes, H-2Aa and H-2Eb. We show that although they are 0.01cM apart, disparate evolutionary patterns were detected. H-2Aa shows higher allelic polymorphism, faster allelic turnover due to higher mutation rates, stronger positive selection at antigen-binding sites and higher population structuring than H-2Eb. H-2Eb alleles are maintained in the gene pool for longer, including over separation of the subspecies, some H-2Eb alleles are positively and others negatively selected and some of the alleles are not expressed." . . . . "\u010C\u00ED\u017Ekov\u00E1, Dagmar" .