. . "P(GA206/08/0640), P(GA206/08/1281), P(LC06073), Z(AV0Z60930519), Z(MSM0021620828)" . . "Functional analysis of the skin-swelling response to phytohaemagglutinin"@en . "Functional analysis of the skin-swelling response to phytohaemagglutinin" . "RIV/68081766:_____/10:00342466" . "259932" . . . "Functional analysis of the skin-swelling response to phytohaemagglutinin"@en . . "2"^^ . "Bainov\u00E1, H." . . . "The phytohaemagglutinin (PHA) skin-swelling test is widely used in immunoecology and ecotoxicology to estimate cell-mediated immunity presumed to reveal T-cell mediated immunocompetence. To investigate the mechanism triggering this response we have compared in zebra finch (Taeniopygia guttata) the immune responses to two PHA isolectins (PHA-L and PHA-E) differing in their biological properties and one control protein. This is the first study to show the importance of erythroagglutination in the development of an inflammatory response to PHA-P. Our results indicate that the skin-swelling test using PHA-P reliably mirrors the individual general proinflammatory potential. The immunological background of the test is highly complex and the test results cannot be interpreted as measurements of the adaptive immunity or T-cell activity. This interpretational change importantly alters our view on the test results regarding the costs of the response or the evolutionary immunological adaptations." . . "3"^^ . . "[2B5ABB5E70AE]" . "Functional analysis of the skin-swelling response to phytohaemagglutinin" . "0269-8463" . "Vinkler, Michal" . "The phytohaemagglutinin (PHA) skin-swelling test is widely used in immunoecology and ecotoxicology to estimate cell-mediated immunity presumed to reveal T-cell mediated immunocompetence. To investigate the mechanism triggering this response we have compared in zebra finch (Taeniopygia guttata) the immune responses to two PHA isolectins (PHA-L and PHA-E) differing in their biological properties and one control protein. This is the first study to show the importance of erythroagglutination in the development of an inflammatory response to PHA-P. Our results indicate that the skin-swelling test using PHA-P reliably mirrors the individual general proinflammatory potential. The immunological background of the test is highly complex and the test results cannot be interpreted as measurements of the adaptive immunity or T-cell activity. This interpretational change importantly alters our view on the test results regarding the costs of the response or the evolutionary immunological adaptations."@en . . . "RIV/68081766:_____/10:00342466!RIV11-GA0-68081766" . "Albrecht, Tom\u00E1\u0161" . . "24" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . "5" . . . . . "avian innate and adaptive immunity; ecoimmunology; ecological immunology; ecotoxicology; inflammatory response; PHA-induced hypersensitivity; phytohaemagglutinin; T-cell-mediated immunocompetence"@en . . "6"^^ . . . . "000281895800016" . . "Functional Ecology" . .