"[7F7F8E24D9CE]" . "193655" . "1043-4666" . . . . . . . "Ko\u010D\u00ED, Lenka" . . . "6"^^ . "TRAIL; anoikis; PI3K/Akt pathway"@en . "Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial" . "Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial"@en . "RIV/68081707:_____/11:00366082!RIV12-AV0-68081707" . "1" . "10.1016/j.cyto.2011.03.013" . . "Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial" . "P(GA301/07/1557), P(GA305/09/1526), P(GA524/07/1178), P(GD303/09/H048), Z(AV0Z50040507), Z(AV0Z50040702)" . . "Cytokine" . . "RIV/68081707:_____/11:00366082" . . . "55" . "The resistance of transformed epithelial cells to a detachment-induced apoptosis (anoikis) can significantly affect their susceptibility to anticancer therapy. We showed that detachment of both fetal (FHC) and adenocarcinoma (HT-29) human colon epithelial cells resulted in the activation of the pro-survival Akt pathway, and significant changes in integrin-linked kinase (ILK) and focal adhesive kinase (FAK) phosphorylation. Our results may have important implications for optimization of new strategies in treatment of cancers at different stages of development."@en . . "Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial"@en . . "H\u00FD\u017E\u010Falov\u00E1, Martina" . . . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Hofmanov\u00E1, Ji\u0159ina" . "Kozub\u00EDk, Alois" . . . "The resistance of transformed epithelial cells to a detachment-induced apoptosis (anoikis) can significantly affect their susceptibility to anticancer therapy. We showed that detachment of both fetal (FHC) and adenocarcinoma (HT-29) human colon epithelial cells resulted in the activation of the pro-survival Akt pathway, and significant changes in integrin-linked kinase (ILK) and focal adhesive kinase (FAK) phosphorylation. Our results may have important implications for optimization of new strategies in treatment of cancers at different stages of development." . . . . "000291916300007" . "Vaculov\u00E1, Alena" . . . "5"^^ . . "5"^^ .