"US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "FGFR3 signaling is capable of inducing premature senescence in chondrocytes, manifested as reversible, ERK-dependent growth arrest accompanied by alteration of cellular shape, loss of the extracellular matrix, upregulation of senescence markers (alpha-GLUCOSIDASE, FIBRONECTIN, CAVEOLIN 1, LAMIN A, SM22alpha and TIMP 1), and induction of senescence-associated beta-GALACTOSIDASE activity. Our data support a model whereby FGFR3 signaling inhibits cartilage growth via exploiting cellular response originally designed to eliminate cells harboring activated oncogenes."@en . "FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence"@en . . . . . . . "Smutn\u00FD, J." . . "FGFR3 signaling is capable of inducing premature senescence in chondrocytes, manifested as reversible, ERK-dependent growth arrest accompanied by alteration of cellular shape, loss of the extracellular matrix, upregulation of senescence markers (alpha-GLUCOSIDASE, FIBRONECTIN, CAVEOLIN 1, LAMIN A, SM22alpha and TIMP 1), and induction of senescence-associated beta-GALACTOSIDASE activity. Our data support a model whereby FGFR3 signaling inhibits cartilage growth via exploiting cellular response originally designed to eliminate cells harboring activated oncogenes." . "Wilcox, W. R." . . "FGFR3; oncogene; skeletal dysplasia"@en . "8756-3282" . "P(GA301/09/0587), S, V, Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622430)" . "[D659A21CF5F2]" . . . "FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence" . . "FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence" . . "FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence"@en . . . "Bone" . "RIV/68081707:_____/10:00345306!RIV11-AV0-68081707" . "Aklian, A." . "Bryja, V\u00EDt\u011Bzslav" . . "3"^^ . . . "000279150400012" . . "Lin, P." . "47" . "Proch\u00E1zkov\u00E1, J." . . "Chlebov\u00E1, K." . . "259031" . "Krej\u010D\u00ED, Pavel" . . . "1" . "9"^^ . "Kozub\u00EDk, Alois" . "RIV/68081707:_____/10:00345306" . . "9"^^ .