. . "[9CE062DADC90]" . "Studovali jsme interakci dinukle\u00E1rn\u00EDho Ru(II) supramolekul\u00E1rn\u00EDho cylindru [Ru2L3]4+ s dvou\u0159et\u011Bzcovou DNA. V\u00FDsledky uk\u00E1zaly, \u017Ee [Ru2L3]4+ rozv\u00EDj\u00ED negativn\u011B nad\u0161roubovicov\u011B zavinutou plasmidovou DNA a vykazuje vazebnou preferenci k pravideln\u011B se st\u0159\u00EDdaj\u00EDc\u00EDm purin-pyrimidinov\u00FDm sekvenc\u00EDm podobn\u011B jako jeho \u017Eelezn\u00FD analog [Fe2L3]4+. Na rozd\u00EDl od [Fe2L3]4+ vykazuje [Ru2L3]41 schopnost zp\u016Fsobovat jedno\u0159et\u011Bzcov\u00E9 zlomy v DNA po oz\u00E1\u0159en\u00ED UVA i viditeln\u00FDm sv\u011Btlem. Ke \u0161t\u011Bpen\u00ED DNA doch\u00E1z\u00ED p\u0159edev\u0161\u00EDm v m\u00EDstech guaninov\u00FDch b\u00E1z\u00ED."@cs . . "7"^^ . "Malina, Jaroslav" . . . . . "P(1QS500040581), P(IAA400040803), P(KAN200200651), P(KJB400040601), P(LC06030), P(ME08017), P(NR8562), Z(AV0Z50040507), Z(AV0Z50040702)" . . "RIV/68081707:_____/08:00318497!RIV09-MZ0-68081707" . . "Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage" . "Chemistry - A European Journal" . . "3"^^ . . "Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage"@en . . . "-" . . . . . "We explored DNA unwinding and sequence-specific binding properties, as well as DNA photonuclease activity of ruthenium(II) metallosupramolecular cylinder [Ru2L3]4+. We found that [Ru2L3]4+ unwinds negatively supercoiled plasmid DNA and exhibits binding preference to regular alternating purine-pyrimidine sequences in a similar way to the [Fe2L3]4+ analogue. [Ru2L3]4+ induces single-strand breaks on irradiation by visible and UVA light and cleaves DNa mainly at guanine residues." . "2"^^ . . . "Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage" . "Interakce dvojjadern\u00FDch Ru(II) supramolekul\u00E1rn\u00EDch cylindr\u016F s DNA. Sekven\u010Dn\u011B specifick\u00E1 vazba, rozv\u00EDjen\u00ED a foto\u0161t\u011Bpen\u00ED"@cs . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "Interakce dvojjadern\u00FDch Ru(II) supramolekul\u00E1rn\u00EDch cylindr\u016F s DNA. Sekven\u010Dn\u011B specifick\u00E1 vazba, rozv\u00EDjen\u00ED a foto\u0161t\u011Bpen\u00ED"@cs . "We explored DNA unwinding and sequence-specific binding properties, as well as DNA photonuclease activity of ruthenium(II) metallosupramolecular cylinder [Ru2L3]4+. We found that [Ru2L3]4+ unwinds negatively supercoiled plasmid DNA and exhibits binding preference to regular alternating purine-pyrimidine sequences in a similar way to the [Fe2L3]4+ analogue. [Ru2L3]4+ induces single-strand breaks on irradiation by visible and UVA light and cleaves DNa mainly at guanine residues."@en . "Hannon, M. J." . "Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage"@en . "DNA unwinding and photocleavage; ruthenium; supramolecular chemistry"@en . "0947-6539" . "372806" . . "000261559400031" . "Brabec, Viktor" . . . . . . "14" . "RIV/68081707:_____/08:00318497" .