. "Topologie DNA ovliv\u0148uje sekven\u010Dn\u011B specifickou vazbu proteinu p53 struktur\u00E1ln\u00EDmi zm\u011Bnami v c\u00EDlov\u00E9 sekvenci"@cs . . "[33437A278C79]" . . . . "Br\u00E1zdov\u00E1 Jagelsk\u00E1, Eva" . . "4"^^ . "P(GA301/05/0416), P(GP301/07/P160), P(IAA500040513), P(IAA500040701), P(KJB500040502), S, Z(AV0Z50040507), Z(AV0Z50040702)" . . "-" . "DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites"@en . "0264-6021" . "7"^^ . "Fojta, Miroslav" . . . . "p53 protein; DNA binding; protein-DNA complex"@en . "364048" . . "DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites"@en . "412" . . "Topologie DNA ovliv\u0148uje sekven\u010Dn\u011B specifickou vazbu proteinu p53 struktur\u00E1ln\u00EDmi zm\u011Bnami v c\u00EDlov\u00E9 sekvenci"@cs . "Vazba proteinu p53 na DNA se zlep\u0161uje se zvy\u0161ov\u00E1n\u00EDm negativn\u00ED supergelik\u00E1ln\u00ED hustoty DNA. C\u00EDlov\u00E9 sekvence proteinu p53 s inverzn\u00ED repetitivn\u00ED sekvenc\u00ED vytv\u00E1\u0159\u00ED v scDNA k\u0159\u00ED\u017Eov\u00E9 struktury. Vytv\u00E1\u0159en\u00ED k\u0159\u00ED\u017Eov\u00E9 struktury u DNA topoizomer\u016F - > 0.05 koreluje s v\u00FDrazn\u00FDm zv\u00FD\u0161en\u00EDm vazby proteinu p53 k DNA."@cs . "RIV/68081707:_____/08:00309774!RIV09-AV0-68081707" . "DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites" . "5"^^ . . "RIV/68081707:_____/08:00309774" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Pe\u010Dinka, P." . "Biochemical Journal" . . . "Br\u00E1zda, V\u00E1clav" . . . "DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites" . . . . . "Binding of p53 to any DNA increased with increasing negative superhelix density. The p53 target sequences possessing the inverted-repeat symmetry were shown to form cruciform structure in sufficiently negative scDNA. We show that formation of the cruciforms in DNA topoisomers at - > 0.05 correlates with the extra enhancement of p53-DNA binding." . . . "000256049800006" . "Binding of p53 to any DNA increased with increasing negative superhelix density. The p53 target sequences possessing the inverted-repeat symmetry were shown to form cruciform structure in sufficiently negative scDNA. We show that formation of the cruciforms in DNA topoisomers at - > 0.05 correlates with the extra enhancement of p53-DNA binding."@en . . . "Pale\u010Dek, Emil" . .