"8"^^ . . . . "Using biochemical methods, the effect of two factors that might play a role in the mechanism of the biological activity of cisplatin at elevated temperatures (<37oC) have been examined. It has been shown that increased temperatures result in distinct alterations in the modification of the target DNA by cisplatin, and in the repair of these modifications. In vitro results support the view that the enhanced DNA-cross-linking efficiency of cisplatin and the lower efficiency of native DNA repair mechanisms at higher temperature play at least a partial role in the potentiation of the antitumor effects of cisplatin under conditions of mild hyperthermia." . . "Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair"@en . . "Using biochemical methods, the effect of two factors that might play a role in the mechanism of the biological activity of cisplatin at elevated temperatures (<37oC) have been examined. It has been shown that increased temperatures result in distinct alterations in the modification of the target DNA by cisplatin, and in the repair of these modifications. In vitro results support the view that the enhanced DNA-cross-linking efficiency of cisplatin and the lower efficiency of native DNA repair mechanisms at higher temperature play at least a partial role in the potentiation of the antitumor effects of cisplatin under conditions of mild hyperthermia."@en . . "Pomoc\u00ED biochemick\u00FDch metod byl zkoum\u00E1n vliv dvou faktor\u016F, kter\u00E9 mohou hr\u00E1t roli v mechanismu biologick\u00E9 aktivity cisplatiny p\u0159i zv\u00FD\u0161en\u00FDch teplot\u00E1ch (<37oC). Bylo uk\u00E1z\u00E1no, \u017Ee zv\u00FD\u0161en\u00E9 teploty maj\u00ED za n\u00E1sledek v\u00FDrazn\u00E9 zm\u011Bny v modifikaci DNA cisplatinou a oprav\u011B t\u011Bchto modifikac\u00ED. V\u00FDsledky studi\u00ED proveden\u00FDch in vitro podporuj\u00ED n\u00E1zor, podle kter\u00E9ho zv\u00FD\u0161en\u00E1 \u00FA\u010Dinnost vytv\u00E1\u0159et v DNA m\u016Fstky a sn\u00ED\u017Een\u00E1 \u00FA\u010Dinnost mechanism\u016F opravy DNA p\u0159i zv\u00FD\u0161en\u00FDch teplot\u00E1ch hraje p\u0159inejmen\u0161\u00EDm \u010D\u00E1ste\u010Dnou roli v zes\u00EDlen\u00ED protin\u00E1dorov\u00FDch efekt\u016F cisplatiny za podm\u00EDnek m\u00EDrn\u00E9 hypertermie."@cs . "Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair"@en . "8" . . "Ka\u0161p\u00E1rkov\u00E1, Jana" . . . "RIV/68081707:_____/07:00092256!RIV08-AV0-68081707" . "P(1QS500040581), P(GA203/05/2032), P(GA305/05/2030), P(GD204/03/H016), P(KAN200200651), P(LC06030), P(NR8562), Z(AV0Z50040507), Z(AV0Z50040702)" . "DNA; ruthenium; cancer"@en . . . . "4"^^ . . "2008;2015" . . "RIV/68081707:_____/07:00092256" . "Vr\u00E1na, Old\u0159ich" . "Chembiochem" . . . "Hal\u00E1mikov\u00E1, Anna" . "411786" . . "1439-4227" . . "4"^^ . "Biochemick\u00E9 studie vlivu tepla na modifikace DNA protin\u00E1dorov\u011B \u00FA\u010Dinnou cisplatinou a jejich opravu"@cs . "[E034946E992F]" . "Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair" . "Brabec, Viktor" . "16" . . "DE - Spolkov\u00E1 republika N\u011Bmecko" . . "Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair" . "Biochemick\u00E9 studie vlivu tepla na modifikace DNA protin\u00E1dorov\u011B \u00FA\u010Dinnou cisplatinou a jejich opravu"@cs . . . . . . . .