. "Brabec, Viktor" . . . . "Bifunk\u010Dn\u00ED arenov\u00E9 komplexy Ru(II) s nav\u00E1zan\u00FDm aminem vytv\u00E1\u0159ej\u00ED na DNA monofunk\u010Dn\u00ED adukty"@cs . "The tethered RuII half-sandwich complexes [\u00E9ta6:\u00E9ta1-C6H5(CH2)nNH2)RuCl2] n=2 or 3 have been synthesized as potential bifunctional anticancer complexes, and their X-ray crystal structures have been determined. These complexes readily ruthenate calf thymus DNA so that only monofunctional DNA adducts are formel. These findings may explain why these complexes exhibit low cytotoxicities toward A2780 human ovarian cancer cells."@en . "46" . . "Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA"@en . . "Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA"@en . "21" . "DNA; ruthenium; cancer"@en . "Bifunk\u010Dn\u00ED arenov\u00E9 komplexy Ru(II) s nav\u00E1zan\u00FDm aminem vytv\u00E1\u0159ej\u00ED na DNA monofunk\u010Dn\u00ED adukty"@cs . . "8950;8962" . . . . "Sadler, P. J." . "Habtemariam, A." . . . "Nov\u00E1kov\u00E1, Olga" . "Fabbiani, F. P. A." . . "RIV/68081707:_____/07:00091784" . . . "Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA" . "2"^^ . "411720" . "Inorganic Chemistry" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Parsons, S." . "Arenov\u00E9 komplexy RuII [\u00E9ta6:\u00E9ta1-C6H5(CH2)nNH2)RuCl2] n=2 nebo 3 byly syntetizov\u00E1ny jako potenci\u00E1ln\u00ED protin\u00E1dorov\u00E1 l\u00E9\u010Diva. Byly tak\u00E9 ur\u010Deny jejich krystalografick\u00E9 struktury. Komplexy se v\u00E1\u017E\u00ED na DNA, a to tak, \u017Ee vytv\u00E1\u0159\u00ED monofunk\u010Dn\u00ED adukty. Tyto v\u00FDsledky mohou vysv\u011Btlit pro\u010D tyto komplexy vykazuj\u00ED pouze slab\u00E9 cytotoxick\u00E9 efekty lidsk\u00FDch ovari\u00E1ln\u00EDch n\u00E1dorov\u00FDch bu\u0148k\u00E1ch A2780."@cs . "13"^^ . "0020-1669" . "8"^^ . "[D0E0ACE097BB]" . . . . "RIV/68081707:_____/07:00091784!RIV08-AV0-68081707" . "Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA" . . . "P(1QS500040581), P(GA203/06/1239), P(GA305/05/2030), P(KAN200200651), Z(AV0Z50040507), Z(AV0Z50040702)" . "The tethered RuII half-sandwich complexes [\u00E9ta6:\u00E9ta1-C6H5(CH2)nNH2)RuCl2] n=2 or 3 have been synthesized as potential bifunctional anticancer complexes, and their X-ray crystal structures have been determined. These complexes readily ruthenate calf thymus DNA so that only monofunctional DNA adducts are formel. These findings may explain why these complexes exhibit low cytotoxicities toward A2780 human ovarian cancer cells." . "Melchart, M." . "Moggach, S. A." .