"P(GA524/05/0595), Z(AV0Z50040507), Z(AV0Z50040702)" . "Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells" . . "M\u00E1jkov\u00E1, Z." . "Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells"@en . "TNF-alpha is known to play a major role in liver regeneration as well as in carcinogenesis. We investigated possible interaction of TNF-alpha with ligands of the AhR. TNF-alpha significantly potentiated proliferative effects of TCDD and PCB126 leading to an increased percentage of cells in S-phase of cell cycle and increased expression of cyclin A. TNF-alpha inhibited AhR-dependent induction of CYP1A1, in contrast, it enhanced induction of CYP1B1." . "0388-1350" . . . "99" . . "tumor necrosis factor-alpha; xenobiotic metabolizing enzymes; dioxin"@en . "Hennig, B." . "TNF-alpha is known to play a major role in liver regeneration as well as in carcinogenesis. We investigated possible interaction of TNF-alpha with ligands of the AhR. TNF-alpha significantly potentiated proliferative effects of TCDD and PCB126 leading to an increased percentage of cells in S-phase of cell cycle and increased expression of cyclin A. TNF-alpha inhibited AhR-dependent induction of CYP1A1, in contrast, it enhanced induction of CYP1B1."@en . "[170141879844]" . . "Zatloukalov\u00E1, Ji\u0159ina" . "RIV/68081707:_____/07:00085551!RIV08-AV0-68081707" . . "Machala, M." . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Umannov\u00E1, Lenka" . . . "8"^^ . . "1" . "Kr\u010Dm\u00E1\u0159, P." . . "TNF-alfa se pod\u00EDl\u00ED na proliferaci a zm\u011Bn\u011B exprese enzym\u016F cytochromu P450 indukovan\u00FDch p\u016Fsoben\u00EDm ligand\u016F Ah receptoru u potkan\u00EDch jatern\u00EDch bun\u011Bk"@cs . . "11"^^ . . . "RIV/68081707:_____/07:00085551" . . "Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells" . "TNF-alfa se pod\u00EDl\u00ED na proliferaci a zm\u011Bn\u011B exprese enzym\u016F cytochromu P450 indukovan\u00FDch p\u016Fsoben\u00EDm ligand\u016F Ah receptoru u potkan\u00EDch jatern\u00EDch bun\u011Bk"@cs . "455972" . . "Toxicological Sciences" . "Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells"@en . . "4"^^ . . "TNF-alfa hraje d\u016Fle\u017Eitou roli b\u011Bhem procesu jatern\u00ED regenerace, stejn\u011B jako p\u0159i vzniku karcinogeneze. V t\u00E9to pr\u00E1ci se zab\u00FDv\u00E1me mo\u017Enou interakc\u00ED TNF-alfa s ligandy AhR. TNF-alfa v\u00FDznamn\u011B posiluje prolifera\u010Dn\u00ED \u00FA\u010Dinky TCDD a PCB126, co\u017E vede ke zv\u00FD\u0161en\u00ED procenta bun\u011Bk v S-f\u00E1zi bun\u011B\u010Dn\u00E9ho cyklu a zv\u00FD\u0161enou expresi cyklinu A. TNF-alfa inhibuje AhR-dependentn\u00ED indukci CYP1A1 a naopak posiluje expresi CYP1B1."@cs . "Vondr\u00E1\u010Dek, Jan" . "79;89" . . . "Kozub\u00EDk, Alois" .