. "4"^^ . "54" . "424925" . "Horv\u00E1th, Viktor" . . "Z(AV0Z50040507)" . "Chemoresistance of ovarian carcinoma cells is a major obstacle in the effective treatment of ovarian and other cancer. The effect of Hsp90 inhibitor Geldanamycin was evaluated alone and in combination with cisplatin in cisplatin resistant cell line A2780cis. Results showed depletion of Akt expression and S-phase arrest after Geldanamycin treatment. Combined exposure of A2780 cells to Geldanamycin and cisplatin resulted in greater than additive cytotoxic effect." . "Sol\u00E1rov\u00E1, Z." . . . "7"^^ . "chemoresistance; cisplatin; Geldanamycin"@en . "Inhibitor Hsp90 Geldanamycin zvy\u0161uje citlivost rezistentn\u00ED bun\u011B\u010Dn\u00E9 linie A2780 poch\u00E1zej\u00EDc\u00ED z adenokarcinomu ov\u00E1ria k cisplatin\u011B"@cs . . . "SK - Slovensk\u00E1 republika" . "Inhibitor Hsp90 Geldanamycin zvy\u0161uje citlivost rezistentn\u00ED bun\u011B\u010Dn\u00E9 linie A2780 poch\u00E1zej\u00EDc\u00ED z adenokarcinomu ov\u00E1ria k cisplatin\u011B"@cs . . "Sol\u00E1r, P." . . . . . "Neoplasma" . "Koval, J." . . "[06A85BDB35F9]" . "2"^^ . "RIV/68081707:_____/07:00082542!RIV07-AV0-68081707" . "Hsp90 inhibitor Geldanamycin increases the sensitivity of resistant ovarian adenocarcinoma cell line A2780cis to cisplatin"@en . "Chemoresistance of ovarian carcinoma cells is a major obstacle in the effective treatment of ovarian and other cancer. The effect of Hsp90 inhibitor Geldanamycin was evaluated alone and in combination with cisplatin in cisplatin resistant cell line A2780cis. Results showed depletion of Akt expression and S-phase arrest after Geldanamycin treatment. Combined exposure of A2780 cells to Geldanamycin and cisplatin resulted in greater than additive cytotoxic effect."@en . "Kozub\u00EDk, Alois" . "Chemorezistence ovari\u00E1ln\u00EDch karcinomov\u00FDch bun\u011Bk je hlavn\u00ED p\u0159ek\u00E1\u017Ekou efektivn\u00EDho l\u00E9\u010Den\u00ED ovari\u00E1ln\u00EDch i jin\u00FDch n\u00E1dor\u016F. V t\u00E9to studii byl hodnocen efekt Hsp90 inhibitoru Geldanamycinu samostatn\u011B nebo v kombinaci s cisplatinou v cisplatina rezistentn\u00ED bun\u011B\u010Dn\u00E9 linii A2780cis. V\u00FDsledky prok\u00E1zaly pokles Akt exprese a arrest v S f\u00E1zi bun\u011B\u010Dn\u00E9ho cyklu v z\u00E1vislosti na p\u016Fsoben\u00ED Geldanamycinu. Kombinovan\u00E9 p\u016Fsoben\u00ED Geldanamycinu a cisplatiny vedlo k v\u00EDce ne\u017E aditivn\u00EDmu cytotoxick\u00E9mu efektu."@cs . . "Hsp90 inhibitor Geldanamycin increases the sensitivity of resistant ovarian adenocarcinoma cell line A2780cis to cisplatin" . "127;130" . . "RIV/68081707:_____/07:00082542" . "0028-2685" . "Hsp90 inhibitor Geldanamycin increases the sensitivity of resistant ovarian adenocarcinoma cell line A2780cis to cisplatin"@en . "2" . "Kleban, J." . . "Fedoro\u010Dko, P." . . "Hsp90 inhibitor Geldanamycin increases the sensitivity of resistant ovarian adenocarcinoma cell line A2780cis to cisplatin" .