. "conformational dynamics; hepatitis delta virus; molecular dynamics"@en . . "Walter, N. G." . "425545" . . . . . . . . . . . "Biopolymers" . . "The self-cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme is buttressed by a trefoil turn pivoting around an extruded G76. In all available crystal structures, the conformation of G76 is restricted by stacking with G76 of a neighboring molecule. To test whether this crystal contact introduces a structural perturbation into a catalytic core, we have analyzed ~200 ns of molecular dynamics simulations." . . "\u0160poner, Ji\u0159\u00ED" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "The self-cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme is buttressed by a trefoil turn pivoting around an extruded G76. In all available crystal structures, the conformation of G76 is restricted by stacking with G76 of a neighboring molecule. To test whether this crystal contact introduces a structural perturbation into a catalytic core, we have analyzed ~200 ns of molecular dynamics simulations."@en . . "15"^^ . "Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme" . . "[1214AA483A7F]" . . "Vliv vyt\u011Bsn\u011Bn\u00E9ho nukleotidu na aktivitu \u0161t\u011Bpen\u00ED a konforma\u010Dn\u00ED dynamiku katalytick\u00E9ho j\u00E1dra hepatitis delta virus ribozymu"@cs . "Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme"@en . "RIV/68081707:_____/07:00081633!RIV07-AV0-68081707" . "3"^^ . "Samo\u0161t\u011Bpen\u00ED HDV ribozymu je esenci\u00E1ln\u00ED pro replikaci HDV, lidsk\u00E9ho patogenu jater. Katalyticky d\u016Fle\u017Eit\u00FD nukleotid C75 je podporov\u00E1n uspo\u0159\u00E1d\u00E1n\u00EDm do trojl\u00EDstku kolem vyt\u011Bsn\u011Bn\u00E9ho G76. Ve v\u0161ech dostupn\u00FDch krystalov\u00FDch struktur\u00E1ch je konformace G76 omezen\u00E1 stackingem s G76 soused\u00EDc\u00ED molekuly. Za \u00FA\u010Delem zjistit, jestli tento krystalov\u00FD kontakt vn\u00E1\u0161\u00ED nebo nevn\u00E1\u0161\u00ED strukturn\u00ED chybu do katalytick\u00E9ho j\u00E1dra, jsme analyzovali cca 200 ns molekulov\u011B dynamick\u00FDch simulac\u00ED."@cs . "5-6" . "RIV/68081707:_____/07:00081633" . "Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme" . . "\u0160pa\u010Dkov\u00E1, Nad\u011B\u017Eda" . "Vliv vyt\u011Bsn\u011Bn\u00E9ho nukleotidu na aktivitu \u0161t\u011Bpen\u00ED a konforma\u010Dn\u00ED dynamiku katalytick\u00E9ho j\u00E1dra hepatitis delta virus ribozymu"@cs . "0006-3525" . . "Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme"@en . "\u0160ef\u010D\u00EDkov\u00E1, J." . . . "392;406" . "5"^^ . "P(1QS500040581), P(GA203/05/0009), P(GA203/05/0388), P(LC512), Z(AV0Z50040507)" . "85" . "Krasovsk\u00E1, Maryna V." .