"The interaction of the diastereomeric complexes delta-[Ru(bpy)2(m-GHK)]Cl2 and lambda-[Ru(bpy)2(m-GHK)]Cl2 (bpy is 2,2'-bipyridine, GHK is glycine-1-histidine-1-lysine) with the deoxyribonucleotide duplex d(5'-CGCGATCGCG)2 was characterized by means of 1H NMR spectroscopy. In addition, photocleavage studies were also conducted with the plasmid pUC19 and a 158-bp restriction fragment, showing that both diastereomers cleave DNA with similar efficiency, attacking mainly the guanines of the sequence probably by generating active oxygen species." . . . "The interaction of the diastereomeric complexes delta-[Ru(bpy)2(m-GHK)]Cl2 and lambda-[Ru(bpy)2(m-GHK)]Cl2 (bpy is 2,2'-bipyridine, GHK is glycine-1-histidine-1-lysine) with the deoxyribonucleotide duplex d(5'-CGCGATCGCG)2 was characterized by means of 1H NMR spectroscopy. In addition, photocleavage studies were also conducted with the plasmid pUC19 and a 158-bp restriction fragment, showing that both diastereomers cleave DNA with similar efficiency, attacking mainly the guanines of the sequence probably by generating active oxygen species."@en . . . "2"^^ . "3" . . "NMR analysis of duplex d(CGCGATCGCG)2 modified by lambda- and delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study"@en . . . "[F9D8F7A00F67]" . "Journal of Biological Inorganic Chemistry" . . "RIV/68081707:_____/07:00081006!RIV07-AV0-68081707" . "P(1P05OC072), P(1QS500040581), P(GA305/05/2030), P(KAN200200651), P(KJB400040601), P(LC06030), Z(AV0Z50040507)" . . "Brabec, Viktor" . "Garoufis, A." . . "NMR analysis of duplex d(CGCGATCGCG)2 modified by lambda- and delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study"@en . "Interakce diastereomern\u00EDch komplex\u016F delta-[Ru(bpy)2(m-GHK)]Cl2 a lambda-[Ru(bpy)2(m-GHK)]Cl2 (bpy je 2,2'-bipyridine, GHK je glycine-1-histidine-1-lysine) s deoxyribonukleotidov\u00FDm duplexem d(5'-CGCGATCGCG)2 byla charakterizov\u00E1na pomoc\u00ED 1H NMR spectroscopie. Krom\u011B toho byly provedeny fotolytick\u00E9 studie s plasmidovou DNA pUC19 a restrik\u010Dn\u00EDm fragmentem dlouh\u00FDm 158 p\u00E1r\u016F b\u00E1z\u00ED, kter\u00E9 uk\u00E1zaly, \u017Ee oba diastereomery \u0161t\u011Bp\u00ED DNA s podobnou \u00FA\u010Dinnost\u00ED zejm\u00E9na v m\u00EDstech guaninov\u00FDch zbytk\u016F pravd\u011Bpodobn\u011B za vzniku aktivn\u00EDch forem kysl\u00EDku."@cs . "0949-8257" . "14"^^ . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "NMR analysis of duplex d(CGCGATCGCG)2 modified by lambda- and delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study" . . "Anal\u00FDza pomoc\u00ED NMR duplexu d(CGCGATCGCG)2 modifikovan\u00E9ho komplexy lambda- a delta-[Ru(bpy)2)m-GHK)]Cl2 a studie fotol\u00FDzy DNA"@cs . . . "Hadjiliadis, N." . . "Malina, Jaroslav" . "RIV/68081707:_____/07:00081006" . "12" . . "5"^^ . "Ru(II); peptide; DNA photocleavage"@en . . . . "279;292" . . "Myari, A." . . "NMR analysis of duplex d(CGCGATCGCG)2 modified by lambda- and delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study" . "437392" . . "Anal\u00FDza pomoc\u00ED NMR duplexu d(CGCGATCGCG)2 modifikovan\u00E9ho komplexy lambda- a delta-[Ru(bpy)2)m-GHK)]Cl2 a studie fotol\u00FDzy DNA"@cs . . .