"8" . "Rybn\u00ED\u010Dkov\u00E1, Hana" . "V p\u0159edlo\u017Een\u00E9 pr\u00E1ci jsou pops\u00E1ny nov\u00E9 analogy transplatiny, u nich\u017E byla jedna aminoskupina nahrazena alifatick\u00FDm a druh\u00E1 plan\u00E1rn\u00EDm heterocyklick\u00FDm ligandem. Tato z\u00E1m\u011Bna m\u00E1 za n\u00E1sledek radik\u00E1ln\u00ED zv\u00FD\u0161en\u00ED aktivity transplatiny v n\u00E1dorov\u00FDch bun\u011B\u010Dn\u00FDch lini\u00EDch a to i u t\u011Bch, kter\u00E9 jsou rezistentn\u00ED k cisplatin\u011B. Biochemick\u00E1 a biofyzik\u00E1ln\u00ED anal\u00FDza interakc\u00ED DNA s nov\u00FDmi komplexy popsan\u00E1 v t\u00E9to pr\u00E1ci ukazuje, \u017Ee vazba studovan\u00FDch komplex\u016F modifikuje DNA zp\u016Fsobem, kter\u00FD je odli\u0161n\u00FD od p\u016Fsoben\u00ED protin\u00E1dorov\u011B neefektivn\u00ED transplatiny a tak\u00E9 od p\u016Fsoben\u00ED protin\u00E1dorov\u011B aktivn\u00EDch transplatinov\u00FDch analog\u016F, u nich\u017E byla zam\u011Bn\u011Bna pouze jedna skupina."@cs . . . . . "platinum drugs; DNA; cancer"@en . . "0022-2623" . . "Brabec, Viktor" . "5"^^ . . . "12"^^ . . "Strukturn\u00ED charakterizace, interakce s DNA a cytotoxicita nov\u00FDch analog\u016F transplatiny obsahuj\u00EDc\u00EDch jeden alifatick\u00FD a jeden plan\u00E1rn\u00ED heterocyklick\u00FD aminov\u00FD ligand"@cs . "2640;2651" . "Navarro-Ranninger, C." . "Structural characterization, DNA interactions, and cytotoxicity of new transplatin analogues containing one aliphatic and one planar heterocyclic amine ligand"@en . . . "8"^^ . "We report in the present work new analogues of transplatin in which one ammine group was replaced by aliphatic and the other by the planar heterocyclic ligand. This replacement results in a radical enhancement of activity of transplatin in tumor cell lines both sensitive and resistant to cisplatin. The biochemical and biophysical analysis of DNa interactions with the new compounds described in this report provides experimental support for the view that the binding of these complexes modifies DNA in a way which is different from that by transplatin and in several features also from other antitumor analogues of transplatin in which only one ammine group was replaced." . "49" . "RIV/68081707:_____/06:00047381" . . "Strukturn\u00ED charakterizace, interakce s DNA a cytotoxicita nov\u00FDch analog\u016F transplatiny obsahuj\u00EDc\u00EDch jeden alifatick\u00FD a jeden plan\u00E1rn\u00ED heterocyklick\u00FD aminov\u00FD ligand"@cs . . "RIV/68081707:_____/06:00047381!RIV07-AV0-68081707" . . "Vr\u00E1na, Old\u0159ich" . . "Hejmalov\u00E1, Lenka" . "Structural characterization, DNA interactions, and cytotoxicity of new transplatin analogues containing one aliphatic and one planar heterocyclic amine ligand" . . . "We report in the present work new analogues of transplatin in which one ammine group was replaced by aliphatic and the other by the planar heterocyclic ligand. This replacement results in a radical enhancement of activity of transplatin in tumor cell lines both sensitive and resistant to cisplatin. The biochemical and biophysical analysis of DNa interactions with the new compounds described in this report provides experimental support for the view that the binding of these complexes modifies DNA in a way which is different from that by transplatin and in several features also from other antitumor analogues of transplatin in which only one ammine group was replaced."@en . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "[12F57D08D5CF]" . "Journal of Medicinal Chemistry" . . . . "P(1QS500040581), P(GA203/05/2032), P(GA305/05/2030), P(GD204/03/H016), Z(AV0Z50040507)" . "Quiroga, Q." . "501919" . "Structural characterization, DNA interactions, and cytotoxicity of new transplatin analogues containing one aliphatic and one planar heterocyclic amine ligand"@en . . . . "Hal\u00E1mikov\u00E1, Anna" . . "Structural characterization, DNA interactions, and cytotoxicity of new transplatin analogues containing one aliphatic and one planar heterocyclic amine ligand" . "Ramos-Lima, F. J." .