"Metal compounds in cancer chemotherapy"@en . "RIV/68081707:_____/05:00023937!RIV06-AV0-68081707" . "Metal compounds in cancer chemotherapy"@en . "Metal compounds in cancer chemotherapy" . "Tento p\u0159ehledn\u00FD \u010Dl\u00E1nek shrnuje ned\u00E1vn\u00E9 pokroky v oblasti v\u00FDvoje protin\u00E1dorov\u011B \u00FA\u010Dinn\u00FDch platinov\u00FDch slou\u010Denin. Podporuje tak\u00E9 n\u00E1zor, podle kter\u00E9ho (i\u00B4) existuje korelace mezi protin\u00E1dorovou aktivitou platinov\u00FDch slou\u010Denin a jejich schopnost\u00ED vyvol\u00E1vat ur\u010Dit\u00FD typ konforma\u010Dn\u00EDch a jin\u00FDch zm\u011Bn v DNA; (ii) tato korelace m\u016F\u017Ee b\u00FDt vyu\u017Eita pro jednoduch\u00E9 testov\u00E1n\u00ED a vyhled\u00E1v\u00E1n\u00ED nov\u00FDch, protin\u00E1dorov\u011B \u00FA\u010Dinn\u00FDch platinov\u00FDch komplex\u016F."@cs . . "P(GA305/05/2030), P(NR8562), Z(AV0Z50040507)" . "2"^^ . "[AA8D03DA345A]" . . "32"^^ . . . . "Kovov\u00E9 slou\u010Deniny v chemoterapii rakoviny"@cs . "Ka\u0161p\u00E1rkov\u00E1, Jana" . "-" . "RIV/68081707:_____/05:00023937" . "187;218" . "DNA; platinum; antitumor"@en . "529653" . "Trivandrum" . . "Kovov\u00E9 slou\u010Deniny v chemoterapii rakoviny"@cs . . "81-7736-277-1" . . "Metal compounds in cancer chemotherapy" . . "Brabec, Viktor" . . . "The present review summarizes recent advances in the area of development of antitumor platinum drugs. It also provides a strong support for the view that (i) there is a correlation between antitumor activity of platinum compounds and their capacility to induce in DNA a certain sort of conformational and other alterations; (ii) this correlation may be exploited for simple screening of new platinum complexes for antitumor activity in the search for new antitumor platinum drugs." . . . . . . . "The present review summarizes recent advances in the area of development of antitumor platinum drugs. It also provides a strong support for the view that (i) there is a correlation between antitumor activity of platinum compounds and their capacility to induce in DNA a certain sort of conformational and other alterations; (ii) this correlation may be exploited for simple screening of new platinum complexes for antitumor activity in the search for new antitumor platinum drugs."@en . "2"^^ . . "Research Signpost" . .