. . "Guanine tetraplex topology of human telomere DNA is governed by the number of (TTAGGG) repeats" . "Topologie guaninov\u00FDch tetraplex\u016F lidsk\u00E9 telom\u00E9rn\u00ED DNA je \u0159\u00EDzena po\u010Dtem opakov\u00E1n\u00ED (TTAGGG)"@cs . . "quadruplexes; human telomere; DNA conformational properties"@en . "0305-1048" . "Secondary structures of the G-rich strand of human telomere DNA fragments G3(TTAG3)n, n=1-16, have been studied by means of CD spectroscopy and polyacrylamide gel electrophoresis, in solutions of physiological potassium cation concentrations. It has been found that folding of these fragments into tetraplexes as well as tetraplex thermostabilities and enthalpy values depend on the number of TTAG3 repeats. The suggested topologies include, for example, antiparallel and parallel bimolecular tetraplexes, an intramolecular antiparallel tetraplex, a tetraplex consisting of three parallel chains and one antiparallel chain a poorly stable parallel intramolecular tetraplex, and both parallel and antiparallel tetramolecular tetraplexes. G3(TTAG3)3 folds into a single, stable, and very compact intramolecular antiparallel tetraplex."@en . "Fialov\u00E1, Mark\u00E9ta" . "Guanine tetraplex topology of human telomere DNA is governed by the number of (TTAGGG) repeats"@en . "5"^^ . . "Kypr, Jaroslav" . . . . "5"^^ . "33" . . . . . "522978" . "Guanine tetraplex topology of human telomere DNA is governed by the number of (TTAGGG) repeats"@en . "5851;5860" . . "Kejnovsk\u00E1, Iva" . . "Guanine tetraplex topology of human telomere DNA is governed by the number of (TTAGGG) repeats" . "[7B695746DB05]" . "Nucleic Acids Research" . "18" . . . "Vorl\u00ED\u010Dkov\u00E1, Michaela" . . . "Chl\u00E1dkov\u00E1, Jana" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . "P(IAA4004201), P(NM7634), Z(AV0Z50040507)" . . "RIV/68081707:_____/05:00022150" . . "RIV/68081707:_____/05:00022150!RIV06-AV0-68081707" . "Pomoc\u00ED cirkul\u00E1rn\u00EDho dichroismu a PAGE byla studov\u00E1na uspo\u0159\u00E1d\u00E1n\u00ED G-bohat\u00FDch fragment\u016F lidsk\u00E9 telomern\u00ED DNA, G3(TTAG3)n (n=1-16) v roztoc\u00EDch fyziologick\u00FDch koncentrac\u00ED K+. Bylo zji\u0161t\u011Bno, \u017Ee tyto fragmenty tvo\u0159\u00ED tetraplexy, jejich\u017E topologie, termostabilita a entalpie jsou z\u00E1visl\u00E9 na po\u010Dtu opakov\u00E1n\u00ED motivu TTAG3. P\u0159edpokl\u00E1dan\u00E1 uspo\u0159\u00E1d\u00E1n\u00ED zahrnuj\u00ED antiparaleln\u00ED a paraleln\u00ED bimolekul\u00E1rn\u00ED tetraplexy, intramolekul\u00E1rn\u00ED antiparaleln\u00ED tetraplex, tetraplex sest\u00E1vaj\u00EDc\u00ED se ze t\u0159\u00ED paraleln\u00EDch \u0159et\u011Bzc\u016F a jednoho antiparaleln\u00EDho \u0159et\u011Bzce, m\u00E1lo stabiln\u00ED paraleln\u00ED intramolekul\u00E1rn\u00ED tetraplex a paraleln\u00ED i antiparaleln\u00ED tetramolekul\u00E1rn\u00ED tetraplexy. G3(TTAG3)3 tvo\u0159\u00ED stabiln\u00ED a velmi kompaktn\u00ED intramolekul\u00E1rn\u00ED antiparaleln\u00ED tetraplex."@cs . . "10"^^ . "Secondary structures of the G-rich strand of human telomere DNA fragments G3(TTAG3)n, n=1-16, have been studied by means of CD spectroscopy and polyacrylamide gel electrophoresis, in solutions of physiological potassium cation concentrations. It has been found that folding of these fragments into tetraplexes as well as tetraplex thermostabilities and enthalpy values depend on the number of TTAG3 repeats. The suggested topologies include, for example, antiparallel and parallel bimolecular tetraplexes, an intramolecular antiparallel tetraplex, a tetraplex consisting of three parallel chains and one antiparallel chain a poorly stable parallel intramolecular tetraplex, and both parallel and antiparallel tetramolecular tetraplexes. G3(TTAG3)3 folds into a single, stable, and very compact intramolecular antiparallel tetraplex." . "Topologie guaninov\u00FDch tetraplex\u016F lidsk\u00E9 telom\u00E9rn\u00ED DNA je \u0159\u00EDzena po\u010Dtem opakov\u00E1n\u00ED (TTAGGG)"@cs .