"P(GA203/05/0009), Z(AV0Z50040507)" . "P\u00E9rez, Alberto" . . . "5062;5066" . "Are the hydrogen bonds of RNA (.U) stronger than those of DNA (A.T)? A quantum mechanics study" . "\u0160poner, Ji\u0159\u00ED" . "Luque, Javier F." . "The intrinsic stabilita of Watson-Crick d(A.T) and r(A.U) hydrogen bonds was analyzed by employing a variety of quantum-mechanical techniques, such as energy calculations, determination of reactivity indexes, and analysis of electron density topology. The analyses was performed on equilibrium gas phase geometries and for hundreds of conformations derived from molecular dynamics (MD) and database analysis. None of our results support the idea that r(A.U) hydrogen bonds are more stable than d(A.T). Instead our data are in accordance with traditional view that the greater stability of RNA relative to DNA is attributable to a variety of effects (e.g. stacking, sugar puckering, solvation etc.)." . . . . . "513050" . "The intrinsic stabilita of Watson-Crick d(A.T) and r(A.U) hydrogen bonds was analyzed by employing a variety of quantum-mechanical techniques, such as energy calculations, determination of reactivity indexes, and analysis of electron density topology. The analyses was performed on equilibrium gas phase geometries and for hundreds of conformations derived from molecular dynamics (MD) and database analysis. None of our results support the idea that r(A.U) hydrogen bonds are more stable than d(A.T). Instead our data are in accordance with traditional view that the greater stability of RNA relative to DNA is attributable to a variety of effects (e.g. stacking, sugar puckering, solvation etc.)."@en . "density functional calculations; DNA; hydrogen bonds"@en . "Are the hydrogen bonds of RNA (.U) stronger than those of DNA (A.T)? A quantum mechanics study"@en . "1"^^ . "Jsou vod\u00EDkov\u00E9 vazby RNA (.U) siln\u011Bj\u0161\u00ED ne\u017E DNA (A.T)? Kvantov\u011B-mechanick\u00E1 studie"@cs . "Jsou vod\u00EDkov\u00E9 vazby RNA (.U) siln\u011Bj\u0161\u00ED ne\u017E DNA (A.T)? Kvantov\u011B-mechanick\u00E1 studie"@cs . . "[8588CF66FF13]" . "RIV/68081707:_____/05:00021195!RIV06-AV0-68081707" . "Hobza, Pavel" . . "Are the hydrogen bonds of RNA (.U) stronger than those of DNA (A.T)? A quantum mechanics study" . "Orozco, Modesto" . "Are the hydrogen bonds of RNA (.U) stronger than those of DNA (A.T)? A quantum mechanics study"@en . "11" . . "6"^^ . . "17" . . "Vnit\u0159n\u00ED stabilita vod\u00EDkov\u00FDch vazeb Watson-Crickov\u00FDch p\u00E1r\u016F d(A.T) a r(A.U) byla anal\u00FDzov\u00E1na zahrnut\u00EDm rozmanit\u00FDch kvantov\u011B-mechanick\u00FDch technik jako v\u00FDpo\u010Dty energie, ur\u010Dov\u00E1n\u00ED index\u016F reaktivity a anal\u00FDza topologie elektronov\u00E9 hustoty. Anal\u00FDza byla d\u011Bl\u00E1na na rovnov\u00E1\u017En\u00FDch geometri\u00EDch v plynn\u00E9 f\u00E1zi a na stovk\u00E1ch konformac\u00ED z\u00EDskan\u00FDch z molekulov\u00E9 dynamiky a datab\u00E1zov\u00E9 anal\u00FDzy. \u017D\u00E1dn\u00FD z na\u0161ich v\u00FDsledk\u016F nepotvrdil my\u0161lenku, \u017Ee r(A.U) vod\u00EDkov\u00E9 vazby jsou stabiln\u011Bj\u0161\u00ED ne\u017E d(A.T)."@cs . "5"^^ . . "0947-6539" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . . "Chemistry European Journal" . "Jure\u010Dka, Petr" . . . "RIV/68081707:_____/05:00021195" . . .