. "\u00DA\u010Dinky parenter\u00E1ln\u00EDch lipidov\u00FDch emulz\u00ED na n\u00E1dorov\u00E9 a norm\u00E1ln\u00ED lidsk\u00E9 epiteli\u00E1ln\u00ED bu\u0148ky kolonu in vitro"@cs . "54" . . . . "\u017D\u010F\u00E1nsk\u00FD, P." . "Physiological Research" . . "Differences in lipid metabolism of tumor and normal tissues suggest a distinct response to available lipid compounds. In this study, the in vitro effects of five types of commercial parenteral lipid emulsions were investigated on human cell lines derived from normal fetal colon (FHC) or colon adenocarcinoma (HT-29). Changes of the cellular lipid fatty acid content, cell oxidative response, and the cell growth and death rates were evaluated after 48 h. No effects of any type of emulsions were detected on cell proliferation and viability. Compared to the controls, supplementation with lipid emulsions resulted in a multiple increase of linoleic and linolenic acids in total cell lipids, but the content of arachidonic, eicosapentaenoic, and docosahexaenoic acids decreased particularly in HT-29 cells." . . "\u00DA\u010Dinky parenter\u00E1ln\u00EDch lipidov\u00FDch emulz\u00ED na n\u00E1dorov\u00E9 a norm\u00E1ln\u00ED lidsk\u00E9 epiteli\u00E1ln\u00ED bu\u0148ky kolonu in vitro"@cs . "RIV/68081707:_____/05:00020904" . . "0862-8408" . "Byly zkoum\u00E1ny in vitro \u00FA\u010Dinky p\u011Bti typ\u016F komer\u010Dn\u00EDch parenter\u00E1ln\u00EDch lipidov\u00FDch emulz\u00ED na lidsk\u00E9 bun\u011B\u010Dn\u00E9 linie odvozen\u00E9 z norm\u00E1ln\u00EDho fet\u00E1ln\u00EDho kolonu (FHC) nebo adenokarcinomu kolonu (HT-29). Po 48 h byly hodnoceny zm\u011Bny obsahu mastn\u00FDch kyselin v bun\u011B\u010Dn\u00FDch lipidech, oxidativn\u00ED metabolismus a bun\u011B\u010Dn\u00FD r\u016Fst a smrt. Ve srovn\u00E1n\u00ED s kontrolou zp\u016Fsobilo p\u0159id\u00E1n\u00ED emulz\u00ED vzr\u016Fst obsahu zejm\u00E9na linoleov\u00E9 kyseliny. Bun\u011B\u010Dn\u00E1 proliferace a viabilita nebyly ovlivn\u011Bny. Koncentrace emulz\u00ED, kter\u00E1 neovlivnila bu\u0148ky HT-29, zv\u00FD\u0161ila mno\u017Estv\u00ED apoptick\u00FDch bun\u011Bk u linie FHC pravd\u011Bpodobn\u011B d\u00EDky oxidativn\u00EDmu stresu, kter\u00FD byl redukov\u00E1n p\u016Fsoben\u00EDm troloxu. V\u00FDsledky ukazuj\u00ED, \u017Ee odpov\u011B\u010F st\u0159evn\u00EDch bun\u011Bk r\u016Fzn\u00E9ho p\u016Fvodu na p\u016Fsoben\u00ED lipidov\u00FDch emulz\u00ED m\u016F\u017Ee b\u00FDt odli\u0161n\u00E1."@cs . "CZ - \u010Cesk\u00E1 republika" . "519603" . . "The effects of parenteral lipid emulsions on cancer and normal human colon epithelial cells in vitro" . "The effects of parenteral lipid emulsions on cancer and normal human colon epithelial cells in vitro"@en . "-" . "Differences in lipid metabolism of tumor and normal tissues suggest a distinct response to available lipid compounds. In this study, the in vitro effects of five types of commercial parenteral lipid emulsions were investigated on human cell lines derived from normal fetal colon (FHC) or colon adenocarcinoma (HT-29). Changes of the cellular lipid fatty acid content, cell oxidative response, and the cell growth and death rates were evaluated after 48 h. No effects of any type of emulsions were detected on cell proliferation and viability. Compared to the controls, supplementation with lipid emulsions resulted in a multiple increase of linoleic and linolenic acids in total cell lipids, but the content of arachidonic, eicosapentaenoic, and docosahexaenoic acids decreased particularly in HT-29 cells."@en . "Hofmanov\u00E1, Ji\u0159ina" . . "4"^^ . "Net\u00EDkov\u00E1, Jarom\u00EDra" . "The effects of parenteral lipid emulsions on cancer and normal human colon epithelial cells in vitro" . . . "Zad\u00E1k, Z." . . . "fat emulsion; reactive oxygen; lipid peroxidation"@en . . . "8"^^ . "The effects of parenteral lipid emulsions on cancer and normal human colon epithelial cells in vitro"@en . . . "RIV/68081707:_____/05:00020904!RIV06-AV0-68081707" . "Kozub\u00EDk, Alois" . "Hy\u0161pler, R." . "10"^^ . . . "[DB903FE9B9BD]" . "409;418" . "Vaculov\u00E1, Alena" . . . . . "P(FD-K/033), P(GA524/03/0766), P(GA524/04/0895), P(GA525/01/0419), P(IBS5004009), Z(AV0Z50040507)" . "Mikeska, J." . .