"Platinum-based drugs" . "Changing the chemical structure of platinum compounds may substantially modulate their DNA binding mode, subsequent processing of DNA damage and consequently the mechanism of biological efficacy of these compounds. These structural modifications may also affect the spectrum of biological activity of the platinum agents and the development of drug resistance, and also their toxicity profile. Complete knowledge of how modifications of DNA by anti-tumor platinum compounds and other metal-based drugs affect the components of these pathways should provide a basis for understanding the mechanism of action of platinum drugs and, thereby, a rational basis for the design of new metal-based drugs and to identify optimal treatment strategies."@en . . "[AEF9E87BF91E]" . . . . . "RIV/68081707:_____/05:00001335" . "P(IAA5004101), P(IBS5004009), P(KJB5004301), Z(AV0Z50040507)" . . . . . "Farmaka odvozen\u00E1 od platiny"@cs . . "0-470-86403-6" . "Platinum-based drugs" . "Metallotherapeutic drugs and metal-based diagnostic agents: the use of metals in medicine" . "536202" . . "RIV/68081707:_____/05:00001335!RIV06-AV0-68081707" . "Platinum-based drugs"@en . "18"^^ . . . . "489;506" . "John Wiley & Sons, Ltd" . "Zm\u011Bny v chemick\u00E9 struktu\u0159e platinov\u00FDch slou\u010Denin mohou podstatn\u00FDm zp\u016Fsobem zm\u011Bnit jejich vazbu k DNA, n\u00E1sledn\u00E9 rozli\u0161en\u00ED takto vznikl\u00E9ho po\u0161kozen\u00ED DNA bun\u011B\u010Dn\u00FDmi proteiny a tedy i mechanismus biologick\u00E9ho p\u016Fsoben\u00ED t\u011Bchto slou\u010Denin. Takov\u00E9 strukturn\u00ED modifikace mohou tak\u00E9 ovlivnit spektrum protin\u00E1dorov\u00E9 aktivity platinov\u00FDch cytostatik a vznik rezistence v\u016F\u010Di t\u011Bmto l\u00E1tk\u00E1m, stejn\u011B tak jako profil jejich toxick\u00E9ho p\u016Fsoben\u00ED. Podrobn\u00E9 znalosti zp\u016Fsobu, jak modifikace DNA protin\u00E1dorov\u011B p\u016Fsob\u00EDc\u00EDmi komplexy platiny a jin\u00FDch kov\u016F ovliv\u0148uj\u00ED biologick\u00E9 procesy, by mohla poskytnout z\u00E1klad pro porozum\u011Bn\u00ED mechanismu cytostatick\u00E9ho p\u016Fsoben\u00ED platinov\u00FDch l\u00E9\u010Div a tedy i racion\u00E1ln\u00ED poznatkovou z\u00E1kladnu pro navr\u017Een\u00ED nov\u00FDch l\u00E9\u010Div na b\u00E1zi t\u011B\u017Ek\u00FDch kov\u016F a pro ur\u010Den\u00ED optim\u00E1ln\u00ED strategie l\u00E9\u010Dby."@cs . "DNA; platinum; cancer"@en . . "2"^^ . . "Ka\u0161p\u00E1rkov\u00E1, Jana" . "2"^^ . . "Platinum-based drugs"@en . "Changing the chemical structure of platinum compounds may substantially modulate their DNA binding mode, subsequent processing of DNA damage and consequently the mechanism of biological efficacy of these compounds. These structural modifications may also affect the spectrum of biological activity of the platinum agents and the development of drug resistance, and also their toxicity profile. Complete knowledge of how modifications of DNA by anti-tumor platinum compounds and other metal-based drugs affect the components of these pathways should provide a basis for understanding the mechanism of action of platinum drugs and, thereby, a rational basis for the design of new metal-based drugs and to identify optimal treatment strategies." . "Brabec, Viktor" . . . "Farmaka odvozen\u00E1 od platiny"@cs . "Chichester" . .