. "1,2-GG intrastrand cross-links formed in DNA by the enantiomeric complexes [PtCl2(R,R-2,3-diaminobutane(DAB))] and [PtCl2(S,S-DAB)] were studied by biophysical methods. Molecular modeling revealed that structure of the cross-links formed at the TGGT sequence was affected by repulsion between the 5,-directed methyl group of the DAB ligand and the methyl group of the 5,-thymine of the TGGT fragment." . "Byly studov\u00E1ny m\u016Fstky vytvo\u0159en\u00E9 v DNA enantiomern\u00EDmi komplexy [PtCl2(R,R-2,3-diaminobutane (DAB))] a [PtCl2(S,S-DAB)] mezi sousedn\u00EDmi zbytky guaninu v jednom \u0159et\u011Bzci metodami molekul\u00E1rn\u00ED biologie, biofyziky a po\u010D\u00EDta\u010Dov\u00E9ho modelov\u00E1n\u00ED. Bylo zji\u0161t\u011Bn\u00E9, \u017Ee zat\u00EDmco strukturn\u00ED naru\u0161en\u00ED vyvolan\u00E1 t\u011Bmito m\u016Fstky vytvo\u0159en\u00FDmi cisplatinou nez\u00E1vis\u00ED na podstat\u011B nukleotid\u016F soused\u00EDc\u00EDch s m\u016Fstkem, strukturn\u00ED naru\u0161en\u00ED vyvolan\u00E1 t\u011Bmito m\u016Fstky vytvo\u0159en\u00FDmi objemn\u011Bj\u0161\u00EDmi platnat\u00FDmi deriv\u00E1ty z\u00E1vis\u00ED."@cs . . . "11"^^ . "DNA; platinum; cancer"@en . . "Kozelka, J." . "1,2-GG intrastrand cross-links formed in DNA by the enantiomeric complexes [PtCl2(R,R-2,3-diaminobutane(DAB))] and [PtCl2(S,S-DAB)] were studied by biophysical methods. Molecular modeling revealed that structure of the cross-links formed at the TGGT sequence was affected by repulsion between the 5,-directed methyl group of the DAB ligand and the methyl group of the 5,-thymine of the TGGT fragment."@en . "2"^^ . "88" . . "RIV/68081707:_____/05:00001325!RIV06-AV0-68081707" . "Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent" . . "4"^^ . "Biophysical Journal" . "Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent"@en . . . "P(GA305/05/2030), P(IAA5004101), P(IBS5004107), Z(AV0Z50040507)" . "Brabec, Viktor" . "4159;4169" . . . . . "Chir\u00E1ln\u00ED rozli\u0161en\u00ED adukt\u016F DNA vytvo\u0159en\u00FDch enantiomern\u00EDmi analogy protin\u00E1dorov\u011B \u00FA\u010Dinn\u00E9 cisplatiny je z\u00E1visl\u00E9 na sekvenci"@cs . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Delalande, O." . . "Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent" . "RIV/68081707:_____/05:00001325" . . "0006-3495" . "Chir\u00E1ln\u00ED rozli\u0161en\u00ED adukt\u016F DNA vytvo\u0159en\u00FDch enantiomern\u00EDmi analogy protin\u00E1dorov\u011B \u00FA\u010Dinn\u00E9 cisplatiny je z\u00E1visl\u00E9 na sekvenci"@cs . . "6" . "Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent"@en . "515206" . "[42647391D73E]" . . "Malina, Jaroslav" . . .