"8"^^ . "gene expression; leukaemia cell line HL60; cDNA"@en . "V p\u0159edkl\u00E1dan\u00E9 studii byly pomoc\u00ED vysokokapacitn\u00EDch cDNA \u010Dipu obsahuj\u00EDc\u00EDch 19,000 sekvenc\u00ED, provedeny studie expresn\u00EDch profil\u016F promyelotick\u00FDch leukemick\u00FDch bun\u011Bk HL-60 diferencuj\u00EDc\u00EDch do monocyt\u016F (MD) a granulocyt\u016F (GD). Jako diferencia\u010Dn\u00ED \u010Dinidlo pro monocyt\u00E1rn\u00ED diferenciaci bylo pou\u017Eito TPA (12-O-tetradecanoylphorbol-D-acetate) a pro granulocyt\u00E1rn\u00ED proces DMSO. Studiem expresn\u00EDch profil\u016F bylo zji\u0161t\u011Bno \u017Ee v pr\u016Fb\u011Bhu MD signifikantn\u011B m\u011Bnilo expresi 4625 gen\u016F a v pr\u016Fb\u011Bhu GD 4760 gen\u016F. Geny obou diferenciac\u00ED byly rozd\u011Bleny do podle typu kinetiky s jakou se \u00FA\u010Dastn\u00ED diferenciace do tzv. R-skupin. Bylo zji\u0161t\u011Bno, \u017Ee geny z jednotliv\u00FDch R-skupin nejsou nen\u00E1hodn\u011B rozprost\u0159eny na chromosomov\u00FDch teritori\u00ED, ale formuj\u00ED na chromosomech klastry. Skupiny genu s podobnou kinetikou regulace tedy m\u016F\u017Eeme naj\u00EDt na chromosomech bl\u00EDzko sebe."@cs . "B\u00E1rtov\u00E1, Eva" . . "Klastrov\u00E1n\u00ED gen\u016F s podobn\u00FDm regula\u010Dn\u00EDm mechanismem b\u011Bhem monocyt\u00E1rn\u00ED a garanulocyt\u00E1rn\u00ED diferenciace bun\u011Bk HL-60"@cs . "Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells" . . . "Biophysics of the Genome: Proceedings of the Workshop Held at Brno" . "Svoboda, Z." . "2"^^ . "Brno" . . "Falt\u00FDskov\u00E1, E." . "Klastrov\u00E1n\u00ED gen\u016F s podobn\u00FDm regula\u010Dn\u00EDm mechanismem b\u011Bhem monocyt\u00E1rn\u00ED a garanulocyt\u00E1rn\u00ED diferenciace bun\u011Bk HL-60"@cs . "Brno" . "Kozubek, M." . . "In the present study, a high density-microarrays of human cDNA containing 19,000 genetic elements were used to search for differences in gene expression of human promyelic leukaemia cell line HL-60 during monocyte (MD) and granulocyte differentiation (GD). For differentiation to monocytes (granulocytes), the TPA, 12-O-tetradecanoylphorbol-D-acetate (DMSO) were used, respectively. A total number of 4625 (4760) genes were found to be regulated during MD (GD). The genes have been divided into groups according to their kinetics of regulation (R-groups). The genes of the same group are not distributed randomly throughout the genome but form clusters on chromosomes (R-clusters). Thus, functionally interconnected genes are frequently localized near to each other on the DNA molecule."@en . "[729E0B245DC0]" . . . "In the present study, a high density-microarrays of human cDNA containing 19,000 genetic elements were used to search for differences in gene expression of human promyelic leukaemia cell line HL-60 during monocyte (MD) and granulocyte differentiation (GD). For differentiation to monocytes (granulocytes), the TPA, 12-O-tetradecanoylphorbol-D-acetate (DMSO) were used, respectively. A total number of 4625 (4760) genes were found to be regulated during MD (GD). The genes have been divided into groups according to their kinetics of regulation (R-groups). The genes of the same group are not distributed randomly throughout the genome but form clusters on chromosomes (R-clusters). Thus, functionally interconnected genes are frequently localized near to each other on the DNA molecule." . . . . . . "557919" . . "Pavl\u00EDk, T." . "Kozubek, Stanislav" . "Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells"@en . "Krontor\u00E1d, P." . . "Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells"@en . . . "38;43" . "P(1A8241), P(GP301/04/P136), Z(AV0Z5004920), Z(MSM 143300002)" . "80-210-3560-9" . "RIV/68081707:_____/04:00108489!RIV/2005/AV0/A17005/N" . "Koutn\u00E1, I." . "Masarykova univerzita v Brn\u011B" . . . "Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells" . "6"^^ . "2004-10-12+02:00"^^ . . . "RIV/68081707:_____/04:00108489" . .