. . . . . "Methylation of histone H3K9 in human blood cells and in granulocytes of patients with myeloid leukemia"@en . "Falk, Martin" . "[5C21DA2DAFDD]" . "Masarykova univerzita v Brn\u011B" . "Methylation of histone H3K9 in human blood cells and in granulocytes of patients with myeloid leukemia"@en . . . "Grigoryev, S." . . "human granulocytes; chromatin condensation; retinoic acid"@en . . "v Antigenn\u00ED markery heterochromatinick\u00FDch protein\u016F, kter\u00E9 jsou b\u011B\u017En\u011B p\u0159\u00EDtomny v j\u00E1drech lidsk\u00FDch progenitorov\u00FDch bun\u011Bk CD34+, diferencovan\u00FDch lymfocyt\u016F a monocyt\u016F, nejsou p\u0159\u00EDtomny v j\u00E1drech neutrofiln\u00EDch a ve zna\u010Dn\u00E9m rozsahu rovn\u011B\u017E eosinofiln\u00EDch granulocyt\u016F. V granulocytech pacient\u016F s akutn\u00ED CML a AML byly detekov\u00E1ny v\u0161echny isoformy HP1 a siln\u00E1 metylace histonu H3K9. V chronick\u00FDch form\u00E1ch CML nebyla nalezen\u00E1 \u017E\u00E1dn\u00E1 siln\u00E1 korelace mezi hladinou metylace histonu H3, progres\u00ED choroby a zp\u016Fsobem l\u00E9\u010Dby. Naprogramov\u00E1n\u00ED leukemick\u00FDch bun\u011Bk HL-60 na termin\u00E1ln\u00ED diferenciaci pomoc\u00ED retinov\u00E9 kyseliny nem\u011Blo za n\u00E1sledek eliminaci metylace histonu H3 a absenci isoforem HP1 proteinu v diferencovan\u00FDch granulocytech. Na\u0161e v\u00FDsledky jsou prvn\u00ED, kter\u00E9 ukazuj\u00ED, \u017Ee metylace histonu H3K9 m\u016F\u017Ee b\u00FDt dramaticky zm\u011Bn\u011Bna v pr\u016Fb\u011Bhu norm\u00E1ln\u00ED bun\u011B\u010Dn\u00E9 diferenciace."@cs . "8"^^ . "Kroupov\u00E1, I." . "Kozubek, Stanislav" . "Methylation of histone H3K9 in human blood cells and in granulocytes of patients with myeloid leukemia" . . . . "P(GA202/02/0804), P(IAA1065203), P(KSK5052113), P(ME 565), P(NC6987), Z(AV0Z5004920)" . "Kozubek, M." . . "Methylation of histone H3K9 in human blood cells and in granulocytes of patients with myeloid leukemia" . "Methylace histonu H3K9 v lidsk\u00FDch krevn\u00EDch bu\u0148k\u00E1ch a v granulocytech pacient\u016F s myeloidn\u00ED leukemi\u00ED"@cs . "Common heterochromatin antigenic protein markers while present in human blood progenitor CD34+ cells, differentiated lymphocytes and monocytes are absent in neutrophile granulocytes and, to large extent, in eosinophiles. In acute CML and AML, strong methylation of H3K9 and all isoformes of HP1 are detected. In chronic forms of CML, no strong correlations among the level of histone methylation, disease progression and modality of treatment were observed. Reprogramming of leukemia HL60 cells to terminal differentiation by retinoic acid does not eliminate histone H3K9 methylation and the presence of HP1 isoformes from differentiated granulocytes. Our study shows for the firs time that histone H3 methylation may be dramatically changed during normal cell differentiation."@en . . . "5"^^ . "4"^^ . "Ko\u0159istek, Z." . "RIV/68081707:_____/04:00108436" . . "53;57" . "Ond\u0159ej, Vladan" . . . . "RIV/68081707:_____/04:00108436!RIV/2005/AV0/A17005/N" . "Brno" . . . "Brno" . "Methylace histonu H3K9 v lidsk\u00FDch krevn\u00EDch bu\u0148k\u00E1ch a v granulocytech pacient\u016F s myeloidn\u00ED leukemi\u00ED"@cs . "Common heterochromatin antigenic protein markers while present in human blood progenitor CD34+ cells, differentiated lymphocytes and monocytes are absent in neutrophile granulocytes and, to large extent, in eosinophiles. In acute CML and AML, strong methylation of H3K9 and all isoformes of HP1 are detected. In chronic forms of CML, no strong correlations among the level of histone methylation, disease progression and modality of treatment were observed. Reprogramming of leukemia HL60 cells to terminal differentiation by retinoic acid does not eliminate histone H3K9 methylation and the presence of HP1 isoformes from differentiated granulocytes. Our study shows for the firs time that histone H3 methylation may be dramatically changed during normal cell differentiation." . "Luk\u00E1\u0161ov\u00E1, Emilie" . . "2004-10-12+02:00"^^ . . . "80-210-3560-9" . "Biophysics of the Genome: Proceedings of the Workshop Held at Brno" . . "573160" .