. . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "1433-7851" . . "Sanz Miguel, P. J." . "Bylo zji\u0161t\u011Bno, \u017Ee sada PtII komplex\u016F obecn\u00E9ho slo\u017Een\u00ED [a3PtC]2+, cis-[a2PtC(OH)]2+, cis-[a2PtC2]2+ a trans-[a2PtCL]n+ (s a = NH3 nebo a3 = dien; C = 1-metyl-cytosin nebo 1,5-dimetylcytosin; L = C nebo jin\u00E1 b\u00E1ze) ve vodn\u00E9m prost\u0159ed\u00ED podstupuje hydrolytickou deaminaci. Mechanismus deamina\u010Dn\u00ED reakce byl objasn\u011Bn pomoc\u00ED DFT v\u00FDpo\u010Dt\u016F a verifikov\u00E1n pomoc\u00ED referen\u010Dn\u00EDch v\u00FDpo\u010Dt\u016F na \u00FArovni CCSD(T). V\u00FDsledky v\u00FDpo\u010Dt\u016F nazna\u010Duj\u00ED, \u017Ee kov na pozici N3 cytosinu slou\u017E\u00ED jako Lewisova kyselina a zprost\u0159edkov\u00E1v\u00E1 nukleofiln\u00ED atak extern\u00ED OH-skupiny na pozici C4."@cs . . "573053" . "A series of cationic PtII complexes of general composition [a3PtC]2+, cis-[a2PtC(OH)]2+, cis-[a2PtC2]2+ and trans-[a2PtCL]n+ (with a = NH3 or a3 = dien; C = 1-methyl-cytosine or 1,5-dimethylcytosine; L = C or other base) has been found to undergo hydrolytic deamination in aqueous solution. The mechanism of the deamination reaction has been enlightened applying DFT (Density Functional Theory) calculations and verified with reference computations at CCSD(T) level of theory. The results of these calculations suggest that the metal at N3 of the cytosine nucleophile acts as a Lewis acid and facilitates the nucleophilic attack of external OH- at the C4 position." . "Metal-mediated deamination of cytosine: experiment and DFT calculations"@en . . . "cytosine; deamination; density functional calculations"@en . . "Metal-mediated deamination of cytosine: experiment and DFT calculations" . . "Sodupe, M." . "43" . "P(LN00A016), Z(AV0Z5004920)" . . "\u0160poner, Judit Erika" . "Deaminace cytosinu pomoc\u00ED kov\u016F: experiment a v\u00FDpo\u010Dty DFT"@cs . . "5396;5399" . . "Erxleben, A." . . "[3B11C7A627A0]" . "Metal-mediated deamination of cytosine: experiment and DFT calculations" . . . . "Deaminace cytosinu pomoc\u00ED kov\u016F: experiment a v\u00FDpo\u010Dty DFT"@cs . "2"^^ . "Angewandte Chemie-International Edition" . . "Krumm, M." . "40" . "A series of cationic PtII complexes of general composition [a3PtC]2+, cis-[a2PtC(OH)]2+, cis-[a2PtC2]2+ and trans-[a2PtCL]n+ (with a = NH3 or a3 = dien; C = 1-methyl-cytosine or 1,5-dimethylcytosine; L = C or other base) has been found to undergo hydrolytic deamination in aqueous solution. The mechanism of the deamination reaction has been enlightened applying DFT (Density Functional Theory) calculations and verified with reference computations at CCSD(T) level of theory. The results of these calculations suggest that the metal at N3 of the cytosine nucleophile acts as a Lewis acid and facilitates the nucleophilic attack of external OH- at the C4 position."@en . "4"^^ . . "Rodr\u00EDguez-Santiago, L." . "Metal-mediated deamination of cytosine: experiment and DFT calculations"@en . "RIV/68081707:_____/04:00104704" . "RIV/68081707:_____/04:00104704!RIV/2005/AV0/A17005/N" . "\u0160poner, Ji\u0159\u00ED" . "8"^^ . . "Lippert, B." .